The current study involves the fabrication of oral bioadhesive bilayer matrices of narrow absorption window drug baclofen and the optimisation of their in vitro drug release and characterisation. Statistical design of experiments, a computer-aided optimisation technique, was used to identify critical factors, their interactions and ideal process conditions that accomplish the targeted response(...

The ultrathin X-ray entrance window for the spaceborne spectrometer SIXA was characterised using synchrotron radiation. X-ray absorption fine structure near the absorption edges of the constituting elements (aluminium, carbon, oxygen and nitrogen) was measured. Large scale positional variations were also studied. In addition, the opacity of the window was tested by observing the effect of photo...

Although it is commonly appreciated that spaced training is superior to massed training in memory formation, the molecular mechanisms underlying this feature of memory are largely unknown. We previously described the selective benefit of multiple spaced (vs massed) training trials in the induction of long-term memory (LTM) for sensitization in Aplysia californica. We now report that LTM can be ...

normal 0 false false false en-us x-none ar-sa background: carbamazepine has been used as aeds since 1965, and is most effective against partial seizures. two basic mechanisms of action have been proposed: 1) enhancement of sodium channel inactivation by reducing high-frequency repetitive firing of action potentials, 2) and action on synaptic transmission. the aim of this study was to provide a ...

A Brownian particle with diffusion coefficient D is confined to a bounded domain by a reflecting boundary, except for a small absorbing window ∂ a . The mean time to absorption diverges as the window shrinks, thus rendering the calculation of the mean escape time a singular perturbation problem. In the three-dimensional case, we construct an asymptotic approximation when the window is an ellips...

A Brownian particle with diffusion coefficientD is confined to a bounded domain of volume V in R by a reflecting boundary, except for a small absorbing window. The mean time to absorption diverges as the window shrinks, thus rendering the calculation of the mean escape time a singular perturbation problem. We construct an asymptotic approximation for the case of an elliptical window of large se...

Observations of the C iv and Mg ii absorption lines in the Seyfert 1 galaxy NGC 4151 obtained with the GHRS in October 1994 are presented. The data from the STScI archive show multiple broad and narrow components in both species. In addition to Galactic absorption, four narrow and four broad systems associated with NGC 4151 are identified. Two broad systems dominate the total equivalent width, ...