Seasonal allergic rhinitic (SAR) subjects are more sensitive to nasal irritants than nonrhinitic (NR) subjects; however, the mechanism underlying this difference is unclear. This study sought to determine whether irritant-induced nasal congestion involves mast cell degranulation. Eight SAR and eight NR subjects were exposed to both 1.0 parts per million chlorine and filtered air in separate vis...

BACKGROUND The CC-chemokine receptor-3 (CCR3) has emerged as a target molecule for pharmacological intervention in allergic inflammation. OBJECTIVE To examine whether a dual CCR3 and H1-receptor antagonist (AZD3778) affects allergic inflammation and symptoms in allergic rhinitis. METHODS Patients with seasonal allergic rhinitis were subjected to three seven days' allergen challenge series. ...

BACKGROUND Several studies have demonstrated the time course of inflammatory mediators in nasal fluids following nasal allergen challenge (NAC), whereas the effects of NAC on cells in the periphery are unknown. We examined the time course of effector cell markers (for basophils, dendritic cells and T cells) in peripheral blood after nasal grass pollen allergen challenge. METHODS Twelve partic...

BACKGROUND Allergic rhinitis is induced by an IgE mediated inflammation after allergen exposure of the membranes lining the nose which, in predisposed individuals, may constitute a risk factor for the occurrence of asthma. OBJECTIVE To detect early changes in nasal inflammation after allergen exposure, 11 children [9.0 (7, 11) yrs], sensitized to house dust mites (HDM), with rhinoconjunctivit...

INTRODUCTION Allergic rhinitis significantly impacts quality of life and current treatments are frequently unsatisfying. VTX-1463 is a potent, selective, Toll-like receptor (TLR) 8 agonist administered weekly via the intranasal route without concomitant administration of allergen for the treatment of allergic rhinitis. AREAS COVERED The rationale for TLR8 as a therapeutic target in allergic d...

Background Allergic rhinitis (AR) and asthma share many characteristics, but structural changes are observed far less often in AR as compared to asthma and also that in nasal polyps. Matrix metalloproteinases (MMPs) can decompose the extracellular matrix and regulate cell infiltration. In order to understand the role of MMPs in AR, we analyzed the expression of MMPs and their inhibitors, tissue...

Methods A preliminary evaluation of the capabilities of the newly constructed Red Maple Trials Allergen Challenge Theatre was performed. Health Canada and a provincial Ethics Board approved the study. After signing informed consent, patients with a history of grass allergy, not on allergy medications and with a positive skin prick test to grass antigen (≥ 3 mm) were exposed for 3 hours to timot...

INTRODUCTION A pathomechanism of allergic rhinitis is complex. A neurogenic mechanism seems to play a significant role in this phenomenon. AIM The evaluation of influence of specific immunotherapy of mugwort pollen allergic patients on the bradykinin concentration in the nasal lavage fluid. MATERIAL AND METHODS The study included 22 seasonal allergic rhinitis patients. Thirty persons with m...