OBJECTIVE 1) To estimate the effectiveness of intranasal administration of CpG DNA alone on allergic rhinitis compared with intradermal administration; and 2) to find out how CpG DNA therapy is useful in treatment of allergic rhinitis. STUDY DESIGN Mice were intraperitoneally sensitized and intranasally challenged with Japanese cedar. Therapy with CpG DNA alone was also performed during chall...

T his issue of American Journal of Rhinology and Allergy (AJRA) covers a diverse selection of articles on basic and clinical aspects of inflamma-tory diseases of the upper airways. One such disease , chronic rhinosinusitis (CRS), significantly lowers quality of life. Despite recent progress, however, CRS remains poorly understood. A few of the articles in this AJRA issue focus on the pathophysi...

Background and objectives The features of bullous pemphigoid (BP) patients presenting with mucosal lesions are not established. We aimed to elucidate the clinical immunological BP involvement, identify factors associated lesions. Patients methods A retrospective study encompassing all consecutive diagnosed throughout years 2009–2019 in a tertiary referral center. Results encompassed 273 BP, who...

BACKGROUND It is widely assumed that apoptosis of eosinophils is a central component of resolution of allergic airway disease. However, this has not been demonstrated in human allergic airways in vivo. Based on animal in vivo observations we hypothesised that steroid-induced resolution of human airway eosinophilic inflammation involves inhibition of CCL5 (RANTES), a CC-chemokine regulating eosi...

INTRODUCTION AND AIM The presented study was undertaken to investigate the respiratory health problems in family barns with one or more cows and at least one family member working in the barn. METHODS 150 workers (128 female, 22 male) from 4 villages of Yığılca district near the city of Düzce in north-west Turkey were enrolled in this study between October - December 2011. An Occupational and...

Nonallergic rhinitis with eosinophilia syndrome (NARES) is a clinical syndrome comprising symptoms consistent with allergic rhinitis in which an absence of atopy has been demonstrated by allergen skin testing, and nasal cytology analysis demonstrates more than 20% eosinophils. Anosmia is a prominent feature not shared with allergic rhinitis. The pathophysiology of NARES is poorly understood, bu...

INTRODUCTION Kimura's disease is a rare chronic inflammatory disease of unknown etiology, presenting as painless subcutaneous nodules with lymphadenopathy and peripheral eosinophilia, mainly disturbing the head and neck region. It mainly affects Asian males in their 2(nd) to 4(th) decade of life. One such case of Kimura's disease, which is uncommon in Indian natives, is reported. CASE REPORT ...