Paliperidone is a well known dopamine antagonist of the atypical antipsychotic class. In the present study Paliperidone was formulated as ER release tablets using natural and synthetic polymers separately or in combination. The aim of ER release formulation is to reduce the frequency of dosing. Tablets are prepared by direct compression method. The optimized formulations contain Paliperidone as...

The application of natural polysaccharides in novel drug delivery systems to deliver the bioactive agents has been hampered by the synthetic polymers. The main benefits of the natural polysaccharides are their being biodegradable, biocompatible, non-toxic, richly available and less expensive. Because of the advances in drug delivery technology, natural polysaccharides are included in novel drug...

The aim of the present study was to evaluate the effect of two chewing gums on the production of volatile sulfur-containing compounds (VSC) in vivo. Fourteen periodontally healthy participants (20-35 years old) were included in the test panel. Test gum 1 (TG1) contained sucrose and Test gum 2 (TG2) contained xylitol and zinc citrate. Two series of tests were conducted with a double-blind cross-...

To understand the effects of adding different gums (guar, xanthan, and locust bean gums) on naked barley flour (NBF), the rheological and pasting properties of NBF-gum mixtures were measured at different gum concentrations (0, 0.3, and 0.6% w/w). Steady shear rheological properties were determined by rheological parameters for power law and Casson models. All samples showed a clear trend of she...

tion of the gums marked by ulceration and ;i tendency to hemorrhage: this is put down to scurvy or to want of cleauliness ; in other words, it is a manifestation of a general condition, or it is merely a local disease. In the majority of cases on careful investigation it will be found to be the latter. As the existence of a scorbutic taint is so frequently diagnosed by a cursory glance at the c...

An increasing interest in the use of natural polymers or gums in pharmaceutical formulations focusing the tremendous orientation to discover and extract such gums. The pharmaceutical industry is ever thirsty to satisfy patient’s therapeutic needs by utilizing inactive excipients along with active ingredients in formulation development. Binders are added to tablet formulations to add cohesivenes...

The exudate gums are complex acidic polysaccharides produced by trees either spontaneously or after mechanical injury. Each polysaccharide contains three or more constituent sugars including D-gluCurOfliC acid (or its 4-methyl ether) and/or D-galacturOniC acid. Highly branched structures are invariably encountered and since each constituent sugar may be present in furanose or pyranose ring form...