OBJECTIVES Discordance between the Gleason score (GS) on needle biopsy (NB) and the GS of the radical prostatectomy (RP) specimen is a common finding. The objective of this study was to evaluate the prognostic significance of these discrepancies with respect to outcomes following RP. METHODS In the study, 6625 men treated by RP were categorized as having NB=RP (68.8%), NBRP ...

The detection of PHOX2B mutations in a small proportion of patients affected with either familial or sporadic neuroblastoma (NB), has arisen interest on the possible pathogenic role of this gene in the disease determination. In this light, we have carried out a quantitative expression analysis of PHOX2B and its paralogue PHOX2A on a panel of NB cell lines and NB tumour samples to identify a pos...

This paper proposes the application of the two well known models of negative binomial regression, namely the NB-1 and the NB-2, and the functional form of negative binomial regression, namely the NB-P, for the analysis of vehicle theft crime. The advantage of using the NB-P is that it parametrically nests both the NB-1 and the NB-2, and allows statistical tests of the NB-1 and the NB-2 models a...

Neuroblastoma (NB) is the most common and aggressive pediatric cancer, characterized by a remarkable phenotypic diversity and high malignancy. The heterogeneous clinical behavior, ranging from spontaneous remission to fatal metastatic disease, is attributable to NB biology and genetics. Despite major advances in therapies, NB is still associated with a high morbidity and mortality. Thus, novel ...

The nucleus basalis (NB) has been implicated in memory formation indirectly, by lesions, pharmacological manipulations, and neural correlates of learning. Prior findings imply that engagement of the NB during learning promotes memory storage. We directly tested this NB-memory hypothesis by determining whether stimulation of the NB induces behavioral associative memory. Rats were trained either ...

OBJECTIVE Although second-trimester nasal bone (NB) hypoplasia has been associated with fetal aneuploidy, its role as a single marker is still uncertain. Our objective was to evaluate the efficiency of NB hypoplasia as an independent marker for fetal aneuploidy. METHODS This was a prospective cohort study of women undergoing an anatomic survey between 16 and 22 weeks' gestation. The fetal NB ...

Neuroblastoma (NB) arises from primitive sympathetic neuroblasts in the adrenal gland or the sympathetic ganglion. NB in situ, sometimes observed in the adrenal glands of autopsied infants, is considered to be a premalignant lesion that may develop into NB. Little is understood about the morphological and biochemical changes that accompany this malignant progression. In this study, a unique mon...

BACKGROUND AND PURPOSE NB-3 is a member of the F3/contactin family of neural recognition molecules, which are crucial for cell morphogenesis and motility. NB-3 is expressed in neurons and plays an important role in axonal extension and neuronal survival. However, the role of NB-3 in cerebral ischemic injury remains unknown. METHODS Adult male wild-type and NB-3 knockout mice were subjected to...

Multifilamentary Nb-Ti superconducting wires with heterogenous flux pinning nano-structures have been fabricated using artificial pinning center (APC) technology. Pinning centers were introduced into Nb-Ti filaments, consisting of Cu-Ni, Nb and Nb+Ti rods with the triangular arrangement and the volume fraction of 17 %. After final hot extrusions, the APC wires were drawn down over a high strain...

conclusion the low prevalence of the nb absence in normal fetuses in the present study is compatible with the larger size of the nb in iranian people compared to other communities. meanwhile, the reference range of the nb length in normal iranian fetuses was established so that basic data could be recorded for further studies regarding the absence or presence of the nb in screening for chromoso...