Homologous recombination between dispersed repeated sequences is important in shaping eukaryotic genome structure, and such ectopic interactions are affected by repeat size and sequence identity. A transformation-based, gap-repair assay was used to examine the effect of 2% sequence divergence on the efficiency of mitotic double-strand break repair templated by chromosomal sequences in yeast. Be...

A large number of rare mutations in the low-density lipoprotein (LDL) receptor gene cause the autosomal dominant disorder familial hypercholesterolemia. In addition, a number of common DNA polymorphisms have been identified in the LDL receptor gene, but their significance in affecting plasma cholesterol levels in the general population has not been studied widely. We investigated the role of tw...

Some 25 years ago [5] it has been suggested that the 14 N (e − , γ) 14 C(α, γ) 18 O reaction (NCO reaction chain) plays a pivotal role in the onset of the Helium flash in the core of a low mass Red Giant Branch (RGB) star (see [3] and [4]). In fact in the He core the Fermi energy is large enough to approach the energy for the e-capture on 14 N well before the 3α reactions produce energy at a si...

Process measurements can be used in an optimization framework to compensate the effects of run-time uncertainty. Among the various options for input adaption, a promising approach consists of directly enforcing the Necessary Conditions of Optimality (NCO) that include two parts: the active constraints and the sensitivities. In this paper, the variations of the NCO under parametric uncertainty a...

Abstract A thermoplastic polyurethane (TPU) series for automotive panels with high durability have been newly synthesized using the reacting process based on polyester polyol (BTG), polycaprolactone triol (PCL), hexamethylene diisocyanate (HDI), isophorone (IPDI), and 1,4-butanediol chain extender as a function of NCO/OH ratio (NCO index). The dependence varying NCO index TPUs tensile strength ...

Four novel 5D (HACA(N)CONH, HNCOCACB, (HACA)CON(CA)CONH, (H)NCO(NCA)CONH), and one 6D ((H)NCO(N)CACONH) NMR pulse sequences are proposed. The new experiments employ non-uniform sampling that enables achieving high resolution in indirectly detected dimensions. The experiments facilitate resonance assignment of intrinsically disordered proteins. The novel pulse sequences were successfully tested ...

Environmentally friendly, polyacrylic-based polyurethane dispersion (PUD) was synthesised using various molar ratios of polycaprolactone, dimethylolpropionic acid and tetramethyl xylene diisocyanate. Synthesis was carried out in flowing nitrogen atmosphere. The PUD’s preparations are free of NMP (n-methyl pyrrolidone), a toxic processing solvent generally used during the preparation of PUD’s. T...

Nursing Care Plans (NCP) and Nursing Clinical Practice Guidelines (NCPG) promote evidence-based patient care, but in their paper form they are difficult to be applied at the point-of-care. We present our approach to generate patient-specific nursing care plans by modeling and computerizing these nursing knowledge resources. We present a Nursing CarePlan Ontology (NCO) that models the NCP and NC...

Sodium (Na)-ion batteries (NIBs) have attracted significant interest as an alternative chemistry to lithium (Li)-ion batteries for large-scale stationary energy storage systems. Discovering high-performance anode materials is a great challenge for the commercial success of NIB technology. Transition metal oxides with tailored nanoarchitectures have been considered as promising anodes for NIBs d...