A 47-year-old woman reported an 18-month-old pretibial rash on her left shin during a routine office visit. She had a history of type 1 diabetes mellitus (DM) and has been on insulin therapy for the past 13 years. She did not complain of any itching, pain, or bleeding from the rash. On examination, an 8 3 cm elongated indurated plaque with telangiectases, central atrophy, and yellow pigmentatio...

Necrobiosis lipoidica is a rare granulomatous and inflammatory disease. Its management is particularly difficult when ulceration is present. The authors describe the clinical case of a 65-year-old female patient with necrobiosis lipoidica, who had been submitted in the past to several topical and systemic treatments with little or no improvement. She started treatment with subcutaneous etanerce...

Introduction: Necrobiosis Lipoidica (NL) had no adequate treatment. Some case has been treated by different vascular lasers. Third generation pulsed dye lasers with a wavelength of 595 nm has been attempted. Their selectively destroys shallower ectatic blood vessels. Material and Methods: We used a 595 nm, Dermobeam 2000 ® laser (manufactured by Deka© MELA Calenzano, Italy), with a dynamic skin...

NL: necrobiosis lipoidica RA: rheumatoid arthritis INTRODUCTION Necrobiosis lipoidica (NL) is a rare, chronic granulomatous disease that affects the dermis with collagen degeneration. It can be associated with several conditions including diabetes mellitus, sarcoidosis, rheumatoid arthritis (RA), inflammatory bowel disease, autoimmune thyroiditis, and monoclonal gammopathy. NL typically develop...