PURPOSE To report the use of corneal collagen crosslinking in the treatment of infective keratitis not responding to antimicrobial therapy. METHODS Two retrospective case reports of infective keratitis treated with corneal collagen crosslinking. RESULTS In both cases, corneal collagen crosslinking caused a rapid resolution of the infective keratitis, leaving residual stromal scarring. Due t...

The efficacy of surgical management of refractory ophthalmic complications of granulomatosis with polyangiitis (GPA), which is a sight threatening was reported. A 70-year-old man presented with a progressively worsening pain and redness in his right eye during the previous 6 months, and decreasing visual acuity that started one month earlier. He was misdiagnosed and treated as keratitis elsewhe...

PURPOSE To describe the treatment of chronic stromal Acanthamoeba keratitis (AK) with oral voriconazole monotherapy. METHODS All cases of chronic stromal AK recalcitrant to traditional therapy subsequently treated with systemic voriconazole seen at the University of Illinois Eye and Ear Infirmary between June 2003 and July 2009 were reviewed for clinical presentation, clinical course, and out...

Pyoderma gangrenosum is an unusual necrotizing noninfective and ulcerative skin disease whose cause is unknown. Ophthalmic involvement in pyoderma gangrenosum is an unusual event. Only a few cases have been reported, from which we can highlight scleral, corneal, and orbital cases. Peripheral ulcerative keratitis is a process which destroys the peripheral cornea. Its cause is still unknown altho...

One potential complication of systemic herpes simplex virus (HSV) vaccination is that subsequent ocular infection may lead to increased immunogenic corneal scarring. Therefore, V52, a genetically engineered vaccinia virus that expresses the HSV-1 glycoprotein gD, was tested for ocular safety and for protection against ocular challenge with a stromal-disease-producing strain (McKrae) of HSV-1. T...

Acanthamoeba keratitis is a type of protozoa keratitis caused by free-living fresh water Amoeba. It recently gains importance because of increasing incidence, difficulty in diagnosis and unsatisfactory treatment. It is seen more commonly in contact lens wear using homemade saline or may be in non-contact lens wearers due to swimming or bathing in contaminated water. This infection is commonly c...

Stromal keratitis resulting from ocular infection with Herpes simplex virus type 1 (HSV-1) is a common cause of blindness. This report investigates the antiviral and anti-inflammatory properties of two new synthetic stigmastane analogs in the experimental model of HSV-1-induced ocular disease in mice. (22S,23S)-22,23-dihydroxystigmast-4-en-3-one (1) and (22S,23S)-22,23-dihydroxystigmasta-1,4-di...

Acanthamoeba keratitis is a type of protozoa keratitis caused by free-living fresh water Amoeba. It recently gains importance because of increasing incidence, difficulty in diagnosis and unsatisfactory treatment. It is seen more commonly in contact lens wear using homemade saline or may be in non-contact lens wearers due to swimming or bathing in contaminated water. This infection is commonly c...

Ophthalmic herpes simplex viral keratitis is responsible for a range of ocular manifestations from superficial epithelial disease to stromal keratitis and endotheliitis. The Herpetic Eye Disease Study has guided the management of herpetic eye disease for almost twenty years, but newer medications such as valacyclovir are now available and are considered to have better bioavailability than acycl...