Relieving perioperative pain can reduce postoperative suffering and improve recovery from anaesthesia in animals. The aim of this study was to compare the analgesic effects of nefopam and tramadol in dogs undergoing ovariohysterectomy. Twenty-four adult mixed-breed female dogs were randomly divided into three groups (n = 8) and received their respective treatments immediately after surgery: Gro...

please cite this article as : moini zanjani t, saghaei e, ameli h, sabetkasaei m. anti-allodynic effect of nefopam and morphine in a rat model of neuropathic pain. novel biomed 2013;1:16-22. background: neuropathic pain is a chronic pain due to a disorder in the peripheral or central nervous system with different pathophysiological mechanisms. current treatments are not effective. here we compa...

BACKGROUND We investigated the effects of the combined administration of nefopam, a N-methyl-D-aspartate receptor antagonist and low dose remifentanil, on early postoperative pain and analgesic requirement. METHODS Fifty patients scheduled to undergo mastoidectomy and tympanoplasty were randomized to be given either nefopam 40 mg mixed with normal saline 100 ml (Group N) or an equal amount of...

Without mentioning chronic pain, acute postoperative pain has been regarded as a matter of great concern to patients as well as physicians. The 'Pain as the Fifth Vital Sign' initiative may have helped make its control of primary importance in the perioperative management of surgical patients [1]. Extensive literature has demonstrated the benefits of effective postoperative pain control includi...

Fibroproliferative disorders include neoplastic and reactive processes (e.g. desmoid tumor and hypertrophic scars). They are characterized by activation of β-catenin signaling, and effective pharmacologic approaches are lacking. Here we undertook a high throughput screen using human desmoid tumor cell cultures to identify agents that would inhibit cell viability in tumor cells but not normal fi...

A new, simple, selective, precise and accurate thin-layer chromatographic method for quantification of nefopam hydrochloride in formulations has been established and validated. TLC F254 silica gel plates in combination with a mixture of chloroform : methanol : glacial acetic acid (9 : 2: 0.1, v/v/v) as mobile phase were used. UV detection was performed densitometrically at a wavelength of 222nm...

Received December 17, 2013. Accepted December 17, 2013. Correspondence to: Sang Wook Shin Department of Anesthesia and Pain Medicine, Pusan National University School of Medicine, Beomeo-ri, Mulgeum-eup, Yangsan 626-770, Korea Tel: +82-55-360-2752, Fax: +82-55-360-2149, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-...