نتایج جستجو برای: neighbor on path nop
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This paper presents a new programming paradigm named Notification Oriented Paradigm (NOP) and analyses performance aspects of NOP programs by means of an experiment. NOP provides a new manner to conceive, structure, and execute software, which allows better performance, causal-knowledge organization, and entity decoupling than standard solutions based upon current paradigms. These paradigms are...
How do changes in the amount and properties of aerosol affect warm clouds? Recent studies suggest that they have opposing effects. Some suggest that an increase in aerosol loading leads to enhanced evaporation and therefore smaller clouds, whereas other studies suggest clouds’ invigoration. In this study, using an axisymmetric bin-microphysics cloud model, we propose a theoretical scheme that a...
PURPOSE Skilled attendance at birth is a proven intervention to improve maternal and newborn health outcomes. Unfortunately, in Nigeria there are many women who give birth alone, with no one present (NOP). The purpose of this study was to document trends in women delivering with NOP between 2003 and 2013, and to identify the characteristics of women who are engaging in this risky practice. ME...
A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102), has been generated by combining in the N/OFQ-NH(2) sequence two chemical modifications, [Arg(14),Lys(15)] and [(pF)Phe(4)], that have been previously demonstrated to increase potency. In vitro, UFP-102 bound with high affinity to the human NOP receptor, showed at least 200-fo...
The Island is a k nearest neighbor query algorithm of moving objects based on road networks and can effectively balance the performance of query and update. But the algorithm doesn’t consider the direction of moving object which is required in many scenarios. It traverses vertexes from all directions, meaning wasting a lot of time in visiting useless vertexes. Besides, it doesn’t return query p...
Nociceptin/orphanin FQ (N/OFQ) has been demonstrated to modulate nociceptive transmission via selective activation of N/OFQ peptide (NOP) receptors. Despite huge research efforts, the role(s) of the endogenous N/OFQ-NOP receptor system in pain processing remains incompletely understood. In the present study, we investigated the role of endogenous N/OFQ in the processing of tonic nociceptive inp...
Location-based localized alternate, disjoint and multi-path routing algorithms for wireless networks
Recently, several fully distributed (localized) location-based routing protocols for a mobile ad hoc network were reported in literature. They are variations of directional (DIR), geographic distance (GEDIR) or progress-based (MFR) routing methods. In DIR methods, each node A (the source or intermediate node) transmits a message m to several neighbors whose direction is closest to the direction...
The GTPase RhoA is a central regulator of cellular contractility in a wide variety of biological processes. During these events, RhoA is activated by guanine nucleotide exchange factors (GEFs). These molecules are highly regulated to ensure that RhoA activation occurs at the proper time and place. During cytokinesis, RhoA is activated by the RhoGEF ECT-2. In human cells, ECT-2 activity requires...
Neuropathic orofacial pain (NOP) is a challenging diagnostic problem. In some cases, symptomatology may be similar to that seen with dental pathology, resulting in unwarranted dental treatment. Rarely, NOP can herald serious disease or central tumors, and early diagnosis can be life-saving. The following review outlines the classification, clinical presentation, pathophysiology, and treatment o...
Nociceptin/orphanin FQ (henceforth N/OFQ) is the endogenous ligand of the so-called nociceptin opioid peptide (NOP) receptor, a.k.a. Opioid Receptor Like 1 (ORL1) receptor, a G-protein coupled receptor which couples to Gi/o and intracellular kinases, among which mitogen-activated protein (MAP) kinases [1]. In 2004, we provided the first evidence that N/OFQ might play a role in Parkinson's disea...
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