Port-site metastases in gynecological malignancies subsequent to laparoscopy have been reported with an incidence of 1.1-16%. These metastases tend to be disappearing after primary debulking surgery and subsequent primary chemotherapy. Local resection, chemotherapy and/or radiotherapy have been defined in the management of these metastases with enhanced clinical success. However, in extremely r...

OBJECTIVE To analyze the expression of hypoxia-inducible factors (hypoxia-inducible factor 1A and hypoxia-inducible factor 2A) and aldehyde dehydrogenase proteins in patients with locally advanced breast carcinoma who were subjected to neoadjuvant chemotherapy. METHODS We included 90 patients with histologically confirmed stage II and III breast carcinoma who were treated with neoadjuvant che...

AIM Radical cystectomy plus platinum-based perioperative chemotherapy is a standard treatment for patients with clinically localized muscle-invasive bladder cancer. The standard perioperative chemotherapy is methotrexate, vinblastine, doxorubicin and cisplatin (MVAC). However, no prospective randomized trial has been published that compares neoadjuvant and adjuvant chemotherapy for bladder canc...

BACKGROUND Randomized trials have shown that neoadjuvant treatment improves survival in the curative treatment of oesophageal and gastro-oesophageal junction cancer. Results from population-based observational studies are, however, sparse and ambiguous. METHODS This prospective population-based cohort study included all patients who had oesophagectomy for cancer in Sweden, excluding clinical ...

BACKGROUND Aim of the study was to assess the value of scintimammography using Tc-99m sestamibi in the evaluation of tumor response to neoadjuvant chemotherapy. MATERIAL ANS METHODS: Results were calculated for 9 patients undergoing neoadjuvant chemotherapy. Scintimammography using 740 MBq Tc-99m sestamibi was performed before, during and after chemotherapy, and sestamibi uptake was scored visu...

The addition of adjuvant or neoadjuvant chemotherapy to surgery revolutionises the treatment of high-grade non-metastatic osteosarcoma of the extremities. Overall 5-year survival of more than 50% to 60% is now a realistic achievable goal. Neoadjuvant chemotherapy possesses the theoretical advantages of optimising surgical results, providing early treatment of micrometastases, allowing histologi...

Historically, neoadjuvant chemotherapy has been used to treat patients with advanced breast disease in an attempt to convert them into candidates for breast conservation surgery. The ultimate goal of histopathologic examination of the specimens removed after neoadjuvant chemotherapy is the identification of either residual disease or positive identification of the tumor bed. We report a series ...

A large proportion of women present with advanced breast cancer in the developing countries with limited resources. Many of these patients have ulcerated, bleeding lesions or visually obvious masses in the breast. Neoadjuvant chemotherapy is well established as the standard of care and initial management of choice for these patients. Tumor shrinkage achieved with neoadjuvant chemotherapy has th...

In non-inflammatory locally advanced breast cancer, treatment typically includes neoadjuvant chemotherapy, surgery, and radiation therapy. Neoadjuvant chemotherapy allows in vivo assessment of primary tumor response to chemotherapy and is achieved the early control of micrometastatic disease. It also significantly improves surgical outcomes. Patients achieving pathologic complete response after...

PURPOSE To define the role of neoadjuvant and concurrent chemotherapy in stage II nasopharyngeal carcinoma, we compared the treatment outcomes of patients treated with curative radiotherapy with or without chemotherapy. MATERIALS AND METHODS From 2004 to 2011, 138 patients with American Joint Committee on Cancer (AJCC) 2002 stage II nasopharyngeal carcinoma were treated with curative radiothe...