نتایج جستجو برای: nephron
تعداد نتایج: 4732 فیلتر نتایج به سال:
MicroRNAs (miRNAs) are small, noncoding regulatory RNAs that act as posttranscriptional repressors by binding to the 3'-untranslated region (3'-UTR) of target genes. They require processing by Dicer, an RNase III enzyme, to become mature regulatory RNAs. Previous work from our laboratory revealed critical roles for miRNAs in nephron progenitors at midgestation (Ho J, Pandey P, Schatton T, Sims-...
The immune system, although regarded as a functional aggregate that acts as a whole, is compartmentalized at the level of many organs, allowing a division of labour during an immune response. The concept of compartmentalization has been recently highlighted in the lymphoid organs and signalled at the level of the digestive and the respiratory tracts. The immune processes take place at the level...
To gain a molecular understanding of kidney functions, we established a high-resolution map of gene expression patterns in the human kidney. The glomerulus and seven different nephron segments were isolated by microdissection from fresh tissue specimens, and their transcriptome was characterized by using the serial analysis of gene expression (SAGE) method. More than 400,000 mRNA SAGE tags were...
Chorioamnionitis is an antecedent of preterm birth. We aimed to determine the effect of experimental chorioamnionitis in fetal sheep during late gestation on 1) nephron number, 2) renal corpuscle volume, and 3) renal inflammation. We hypothesized that exposure to chorioamnionitis would lead to inflammation in fetal kidneys and adversely impact on the development of nephrons, leading to a reduct...
Partial urinary tract obstruction is known to produce, in addition to a nonspecific depression in renal function, certain characteristic derangements, especially profound polyuria (1-5); release of the obstruction may result in a transient salt-wasting state (6, 7). Three hypotheses may be advanced to explain the altered function of the hydronephrotic kidney. It is possible that with the elevat...
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