To the Editor: Netherton syndrome (NS) is a rare autosomal recessive ichthyosis due to loss-of-function mutations in SPINK5 encoding LEKTI.1Chavanas S. Bodemer C. Rochat A. et al.Mutations SPINK5, serine protease inhibitor, cause syndrome.Nat Genet. 2000; 25: 141-142Crossref PubMed Scopus (659) Google Scholar Patients with NS typically present linearis circumflexa (NS-ILC) or scaly erythroderma...

Atopic is the most common of the dermatitides seen in infancy and childhood, but there are numerous other diseases that can mimic the skin findings. These include seborrheic dermatitis, immunodeficiency, and psoriasis in infancy; scabies, tinea corporis infection, perioral, nummular, contact, and molluscum dermatitis in childhood. It is sometimes extremely difficult to differentiate between ich...

BACKGROUND Impaired skin integrity in patients with Netherton syndrome (NS) results in significant systemic absorption of topically applied medications. Some have advocated the administration of pimecrolimus, 1%, topical cream for the treatment of patients with NS. Insufficient data exist with regard to its safety, systemic absorption, and efficacy. OBSERVATIONS An exploratory study was condu...