Dr. Dimitris Vasiliadis is currently head of the Network Operations Center (NOC) of Technological Educational Institute (T.E.I.) of Epirus, a node of the Greek Research and Technology Network (GRNET). He has published more than 30 papers. He has been a PC member and referee in various international journals and conferences. His research interests include Performance Analysis of Networking and C...

The interpretation of ChIP-chip data poses two computational challenges: first, what can be termed primary statistical analysis, which includes quality assessment, data normalization and transformation, and the calling of regions of interest; second, integrative bioinformatic analysis, which interprets the data in the context of existing genome annotation and of related experimental results obt...

UNLABELLED In many genomic studies, one works with genome-position-dependent data, e.g. ChIP-chip or ChIP-Seq scores. Using conventional tools, it can be difficult to get a good feel for the data, especially the distribution of features. This article argues that the so-called Hilbert curve visualization can complement genome browsers and help to get further insights into the structure of one's ...

High-throughput, microarray-based chromatin immunoprecipitation (ChIP-chip) technology allows in vivo elucidation of transcriptional networks. However this complex is not yet readily accessible, in part because its many parameters have not been systematically evaluated and optimized. We address this gap by systematically assessing experimental-design parameters including antibody purity, dye-bi...

Upon developmental or environmental cues, the composition of transcription factors in a transcriptional regulatory network is deeply implicated in controlling the signature of the gene expression and thereby specifies the cell or tissue type. Novel methods including ChIP-chip and ChIP-Seq have been applied to analyze known transcription factors and their interacting regulatory DNA elements in t...

Recent advances in the silicon technology is enabling the VLSI chips to accommodate billions of transistors; leading toward incorporating hundreds of heterogeneous components on a single chip. However, it has been observed that the scalability of chips is posing grave problems for the current interconnect architecture which is unable to cope with the growing number of components on a chip. To r...

Traditional bus-based interconnects are simple and easy to implement, but the scalability is greatly limited. While router-based networks-on-chip (NoCs) offer superior scalability, they also incur significant power and area overhead due to complex router structures. In this paper, we explore a new class of on-chip networks, referred to as Routerless NoCs, where routers are completely eliminated...