The aim of the present study was to investigate the influence of classic and atypical neuroleptics on the activity of rat CYP2C6 measured as a rate of warfarin 7-hydroxylation. The reaction was studied in control liver microsomes in the presence of neuroleptics, as well as in microsomes of rats treated intraperitoneally for one day or two weeks (twice a day) with pharmacological doses (mg/kg) o...

Although poor response to neuroleptics has traditionally been considered a characteristic feature of negative schizophrenic symptoms, several recent studies have documented significant improvement in negative symptoms in schizophrenic patients treated with neuroleptics. The question of whether neuroleptic-induced improvement in negative symptoms is linked to concomitant improvement in positive ...

A young manic patient who showed poor response to lithium, neuroleptics and ECT and developed severe cxtrapyramidal side effects restricting the use of neuroleptics in high doses; showed marked clinical improvement with a combination of carbamazepine and lithium with sustained recovery. The case reported to illustrate the possible synergistic action suggested earlier, encouraging the authors to...

The aim of the present study was to investigate the influence of classic and atypical neuroleptics on the activity of rat CYP2C6 measured as a rate of warfarin 7-hydroxylation. The reaction was studied in control liver microsomes in the presence of neuroleptics, as well as in microsomes of rats treated intraperitoneally for one day or two weeks (twice a day) with pharmacological doses (mg/kg) o...