APS is an auto immune disease in which auto antibodies are detected against cell membrane phospholipids and is clinically characterised mainly by thrombocytopenia, thrombosis, neurologic and dermatologic manifestation and recurrent fetal loss. More recently it is found that these antibodies react with specific plasma proteins associated with phospholipids (e.g. β2 glycoprotein1 β2gp1) rather th...

Wernicke-Korsakoff syndrome is a manifestation of thiamine (vitamin B1) deficiency, usually secondary to alcohol abuse, although there other non-alcohol related causes, such as bariatric surgery, and extreme dietary restriction. The syndrome is a combined manifestation of the short-lived but acute Wernicke’s encephalopathy (WE), followed by chronic Korsakoff syndrome. It is generally accepted t...

To determine the epidemiologic and clinical features of a 2008 outbreak of Hendra virus infection in a veterinary clinic in Australia, we investigated the equine case-series. Four of 5 infected horses died, as did 1 of 2 infected staff members. Clinical manifestation in horses was predominantly neurologic. Preclinical transmission appears likely.

this is a report of a case with unilateral cavernous sinus thrombosis due to ipsilateral ethmoid sinusitis. a 10 year old female was admitted in our hospital with severe headache, purulent postnasal discharge, right eye proptosis and third cranial nerve palsy in the same eye. she had history of viral upper respiratory tract infection and then acute otitis media which did not improve with routin...

Enterovirus 71 frequently involves the central nervous system and may present with a variety of neurologic manifestations. Here, we aimed to describe the clinical features, magnetic resonance imaging (MRI) findings, and cerebrospinal fluid (CSF) profiles of patients presenting with neurologic complications of enterovirus 71 infection. We retrospectively reviewed the records of 31 pediatric pati...

OBJECTIVES To further characterize mtDNA defects associated with autistic features, especially the A3243G mtDNA mutation and mtDNA depletion.Study design Five patients with autistic spectrum disorders and family histories of mitochondrial DNA diseases were studied. We performed mtDNA analysis in all patients and magnetic resonance spectroscopy in three. RESULTS Three patients manifested isola...

neurological manifestation may complicate takayasu arteritis (ta). a 23-year-old girl with sudden onset of vision loss was admitted to hospital. her brain mri showed abnormal t2-signal hyperintensity and visual evoked potential revealed prolonged p100 latency. consequently, optic neuritis was diagnosed. a review on history of dizziness, falling, and weak pulses of upper extremities led to more ...

Paraneoplastic disorders of the nervous system are important to the practicing oncologist, because these syndromes, although uncommon, produce significant neurologic dysfunction and disability. The neurologic disorder may be the first manifestation of an unrecognized systemic malignancy, and appropriate diagnosis of the paraneoplastic disorder can lead to a focused search for an underlying canc...

context of migraine Having read the January 2007 issue of the Journal with the very interesting and well-written article on menstrual migraine by Anne MacGregor,1 I was surprised to read the words flickering lights (Box 1; 1.2.1 Typical aura with migraine headaches B.1.) in the context of migraines with aura. This is confusing as the UK Medical Eligibility Criteria for Contraceptive Use2 seems ...

Children with rheumatic disorders may have a wide variety of clinical features ranging from fever or a simple arthritis to complex multisystem autoimmune diseases. Information about the prevalence of neurological manifestations in children with rheumatologic disorders is limited. This review describes the neurologic complications of childhood Rheumatic disease either solely or combined with sym...