BACKGROUND Neuromyelitis optica is a severely disabling inflammatory disorder of the central nervous system of autoimmune etiology that mainly affects the optic nerves and spinal cord. Here, we present a case report detailing a patient with tingling and weakness of right upper and lower limbs who was neuromyelitis optica immunoglobulin G-positive. CASE PRESENTATION A 46-year-old Nepalese man ...

Central or peripheral demyelinating disorders including neuromyelitis optica, isolated optic neuritis or myelitis, and Guillain-Barre syndrome (GBS) in patients with tuberculosis have been well documented in the literature. , 2 It has been suggested that they are most likely due to an immune reaction to tuberculosis rather than due to direct invasion of tuberculosis or the adverse effect of ant...

Background: Neuromyelitis Optica (NMO) is an autoimmune inflammation of the central nervous system in which autoantibodies are released against Aquaporin-4 (AQP-4), astrocytic water channels. The disease is characterized by transverse myelitis and optic neuritis. Viruses could be inflammatory agents in the brain. Due to such inflammatory reactions, autoantibodies would cross the blood brain bar...

Abstract Background Neuromyelitis optica is a rare immune-mediated demyelinating central nervous system disorder affecting the spinal cord and optic nerves. There no permanent cure for this disease, its management requires multidisciplinary approach. Objective The objective of case report to see effectiveness physical therapy in neuromyelitis Optica. Methods A 13-year-old female with symptoms l...

OBJECTIVES Since Devic's original description of neuromyelitis optica in 1894 there has been much debate regarding its aetiology. A specific cause has been identified in a minority of cases but in most the question has arisen whether or not Devic's neuromyelitis optica is a variant of multiple sclerosis. This study was undertaken to help clarify this issue. METHODS Neuromyelitis optica was de...

Neuromyelitis optica (NMO) is a rare disorder in children with variable presentation. We report a 7-year-old boy who presented with bilateral retrobulbar optic neuritis and responded very well to treatment. He was also positive for aquaporin 4 (AQP4) antibodies, which is part of an emerging endophenotype within autoimmune neurological disorders in childhood.

Extensive optic nerve demyelinating lesions on magnetic resonance imaging (MRI) in adults could indicate a diagnosis other than multiple sclerosis with worse prognosis such as neuromyelitis optica. We report the frequency of longitudinally extensive lesions in children with first events of optic neuritis. Subjects had brain or orbit MRI within 3 months of onset and were evaluated at the Univers...

Neuromyelitis optica or Devic`s disease is an inflammatory disimmune-neurodegenerative characterized by a progressive course, predominantly affecting the optic nerves and spinal cord, with relatively intact brain structures. The differential diagnosis of neuromyelitis multiple sclerosis based on identification typical clinical tomographic picture presence high level antibodies to aquaporin 4 in...

Background: Neuromyelitis optica spectrum disorder (NMOSD) has emerged as a disorder distinct from multiple sclerosis, largely due to the discovery in 2004 of a novel disease marker, aquaporin-4 immunoglobulin or AQP4-IgG (also known as NMO-IgG). Differentiating NMOSD from multiple sclerosis has important prognostic and treatment implications. The features of pediatriconset multiple sclerosis h...

Neuromyelitis optica (NMO) has been traditionally described as the association of recurrent or bilateral optic neuritis and longitudinally extensive transverse myelitis (LETM). Identification of aquaporin-4 antibody (AQP4-IgG) has deeply changed the concept of NMO. A spectrum of NMO disorders (NMOSD) has been formulated comprising conditions which include both AQP4-IgG seropositivity and one of...