There is emerging evidence for multifarious neurological manifestations of coronavirus disease 2019 (COVID-19), but little known regarding whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) a specific biomarker neuronal injury. We measured sNfL concentrations 29 critically ill COVID-19 patients, 10 non–COVID-19 and 259 healthy controls. After ad...

Understanding of the pathophysiology of neuronal injury has advanced remarkably in the last decade. This largely reflects the burgeoning application of molecular techniques to neuronal cell biology. Although there is certainly no consensus hypothesis that explains all aspects of neuronal injury, a number of interesting observations have been published. In this brief review, we examine mechanism...

back ground  subsequent to spinal cord injury many pathological changes may occur that could lead to inappropriate environment for repair. the most important of such changes is the death of neurons. exogenous administration of growth factors that modulate neuronal survival, synaptic plasticity, and neurotransmission has been proposed as a potential therapeutic treatment for sci. among these gro...

spinal cord injury (sci)-induced systemic inflammatory response affects multiple organs outside the spi­nal cord. treatment options for such complications are lacking. valproic acid (vpa) is a histone deacetylase inhibitor, acting directly at the level of gene transcription by inhibiting histone deacetylation and making transcription sites more accessible. acetylation of histones is critical to...

There is a rising intracellular Zn2+ transient during neuronal ischemic hypoxia (oxygen-glucose deprivation and reoxygenation, OGD/R). The results of our recent works suggest that the OGD/R-induced Zn2+ transient can readily be mistaken for a Ca2+ transient. The aim of this study was to examine the respective functions of Zn2+ and Ca2+ in OGD/R-induced neuronal injury. We showed that [Zn2+]i ac...

Hypoxic-ischemic (HI) injury to developing brain results from birth asphyxia in neonates and from cardiac arrest in infants and children. It is associated with varying degrees of neurologic sequelae, depending upon the severity and length of HI. Global HI triggers a series of cellular and biochemical pathways that lead to neuronal injury. One of the key cellular pathways of neuronal injury is i...