The hypothalamus is an important component of the nervous system, and neuropeptide Y (NPY), proopiomelanocortin (POMC), and neuromedin U (NMU) are key players in physiological regulation. Puerarin is important for nerve regulation. We investigated the effect of puerarin on the expression of NMU, NPY, and POMC genes in the hypothalamus. The results showed that the puerarin low-dose group and the...

Background Neuropeptide Y is a highly conserved 36 amino acid peptide that is widely distributed in the peripheral and central nervous systems. Besides its functions in various metabolic processes, NPY has attracted considerable attention in modulating emotional-affective behavior. NPY exerts a solid anxiolytic effect most likely mediated by Y1 receptors, whereas stimulation of predominantly pr...

Disturbances in crosstalk between the immune system and the sympathetic nervous system (SNS) can contribute to the pathogenesis of Th1-mediated autoimmunity. Recent studies indicate that neuropeptide Y (NPY) has a major role in the regulation of Th1 responses. The precise role of NPY has been an enigma, but a recent study provides a breakthrough, demonstrating that NPY has a bimodal role as a n...

To determine whether neuropeptide Y (NPY)-related mechanisms become activated with progression of cardiac hypertrophy in vivo, protein mass and de novo protein synthesis (incorporation of [(14)C]Phe, 0.1 muCi ml(-1)) were assessed in cardiomyocytes, obtained from spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (8, 12, 16, 20, and 24 weeks of age), and cultured for 24 h...

introduction: numerous studies have demonstrated that kisspeptin, a peptide from the kiss1 gene, plays an important role in regulating the secretion of gonadotropin releasing hormone (gnrh). also, there is some evidence suggesting that kisspeptin can interact with other neuropeptides for the control of the reproductive axis. in the present study, we have investigated the effect of central admin...

Background Neuropeptide Y (NPY), a highly conserved 36 amino acid peptide, is widely distributed in the central nervous system. Besides its functions in various metabolic processes NPY has attracted considerable attention in modulating emotional-affective behavior. NPY exerts a pronounced anxiolytic effect most likely mediated by Y1 receptors, whereas stimulation of predominantly presynaptic Y2...

Ma huang, the dried plant stem of ephedra intermedia Schrenk et C.A., contains an ephedrine-type alkaloid and has been used for weight loss. Neuropeptide Y (NPY), a 36-amino acid peptide, is concentrated in the hypothalamus and stimulates feeding desire. In this study, the effect of ma huang on the expressions of NPY in the hypothalamus of rats was investigated using immunohistochemistry. Food-...

Hypothalamic neurons that express neuropeptide Y (NPY) and agouti-related protein (AgRP) are thought to be critical regulators of feeding behavior and body weight. To determine whether NPY/AgRP neurons are essential in mice, we targeted the human diphtheria toxin receptor to the Agrp locus, which allows temporally controlled ablation of NPY/AgRP neurons to occur after an injection of diphtheria...