In the last years, physiological aging became a general concept that includes all the changes that occur in organism with old age. It is obvious now, that in developing and developed countries, new health problems concerning older population appear. One of these major concerns is probably dementia. Sooner or later, all forms of dementia lead to learning deficit, memory loss, low attention span,...

Currently, there is still no effective therapy for neurodegenerative diseases (NDD) such as Alzheimer's disease (AD) and Parkinson's disease (PD) despite intensive research and on-going clinical trials. Collectively, these diseases account for the bulk of health care burden associated with age-related neurodegenerative disorders. There is therefore an urgent need to further research into the mo...

Gunnar Hargus1,3 and Christian Bernreuther1,2 1Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, University of Hamburg, Martinistr. 52, 20246 Hamburg, 2Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany 3present address: Udall Parkinson ́s Disease Research Center of Excel...