The high signal intensities in bilateral mesiotemporal lobes on T2-weighted images are typical findings of herpes encephalitis or paraneoplastic limbic encephalitis. We report a case of neurosyphilis with mesiotemporal involvement on MRI. Positive antibodies in the cerebrospinal fluid confirmed the diagnosis. The results suggest that neurosyphilis should be considered when MRI results indicate ...

Syphilis is still a significant public health problem in developing countries. Although chorea is a very rare manifestation of neurosyphilis, it might be on occasions the initial symptom. This report presents a patients with neurosyphilis who had chorea as the initial presenting symptom.

Neurosyphilis is a complication of systemic syphilis. This review of the clinical presentation, diagnostic laboratory findings, treatment and management of neurosyphilis discusses the impact of HIV and the specific challenges it brings, focusing on areas of controversy, and highlighting important questions that remain to be answered.

This case report presents the of a 58-year-old Caucasian male with hypercapnic respiratory failure (type 2 failure) and septic shock attributed to pneumonia. He also had multiorgan dysfunction was subsequently diagnosed neurosyphilis in setting underlying HIV. The patient initially presented worsening shortness breath bilateral lower extremity edema. Further evaluation revealed HIV positivity i...

Thirty-six patients with reactive results in the cerebrospinal fluid to the Treponema pallidum haemagglutination assay (CSF-TPHA) were investigated by further serological tests for confirmation of active neurosyphilis. The results of the TPHA and fluorescent treponemal antibody tests were reactive in all CSF samples from patients with acute untreated neurosyphilis and from most patients with la...

OBJECTIVE To determine the usefulness of cerebrospinal fluid tests in the diagnosis of neurosyphilis. METHODS Two hundred and seven cerebrospinal fluid-Venereal Disease Research Laboratories tests were performed at King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia between 1992 and 1997. The records of 14 cases with progressive neurological disease and reactive serum fl...

A case of parkinsonism associated with neurosyphilis, which improved markedly after appropriate treatment, is described. Although neurosyphilis is a rare cause of parkinsonism, it should be considered when parkinsonism appears in the 30-50-year age group, particularly if other anomalous neurological findings are present. Adequate therapy may improve the patient's condition and prevent further p...

Two patients developed neurosyphilis after treatment of latent syphilis with intramuscular benzathine penicillin. The cases confirm recent investigations that show that neither benzathine penicillin nor procaine penicillin in the standard doses results in treponemicidal concentrations of penicillin in cerebrospinal fluid. Neurosyphilis can be treated effectively by intravenous benzylpenicillin ...

OBJECTIVES To review the management of a cohort of patients with positive treponemal serology and psychiatric and/or neurological disorders. METHODS A retrospective case note review of 172 patients with positive treponemal serology attending the Patrick Clement's Clinic, Central Middlesex Hospital between December 1990 and November 1995 was performed. RESULTS 101 men and 71 women were new a...

BACKGROUND Known predictors of neurosyphilis were mainly drawn from human immunodeficiency virus (HIV)-infected syphilis patients, which may not be applicable to HIV-negative populations as they have different characteristics, particularly those with neurological symptoms. This study aimed to identify novel predictors of HIV-negative symptomatic neurosyphilis (S-NS). METHODS From June 2005 to...