In recent decades, the increasing prevalence of age-associated neurodegenerative diseases has underscored the need for targeted therapeutic strategies and novel diagnostics. Peptide-based neurotherapeutics offer high specificity and tolerability but are limited by proteolytic degradation in vivo. Peptoids, or N-substituted glycines, are versatile peptidomimetics that evade proteolytic degradati...

Impaired nerve regeneration and inadequate recovery of motor and sensory function following peripheral nerve repair remain the most significant hurdles to optimal functional and quality of life outcomes in vascularized tissue allotransplantation (VCA). Neurotherapeutics such as Insulin-like Growth Factor-1 (IGF-1) and chondroitinase ABC (CH) have shown promise in augmenting or accelerating nerv...

The 15th Annual Meeting of the Cognitive Neuroscience Society brought together researchers and exhibitors to discuss and present data relevant to the study of the mind using neuroscience methods, especially neuroimaging. A history of interdisciplinary communication, which was the basis of the creation of this society, continues to expand the scope of work presented at the meeting to include res...

1 Parkinson’s Disease and Dystonia Research Centre, Tokushima University Hospital, University of Tokushima, Tokushima 770-8503, Japan 2 Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medical Sciences, University of Tokushima, Tokushima 770-8503, Japan 3 Department of Neurosurgery, Institute of Health Biosciences, Graduate School of Medical Sciences, Uni...

Aida Habtezion,* Raymond Kwan,* Alice L. Yang, Maureen E. Morgan, Ehsaan Akhtar, Stephen P. Wanaski, Stephen D. Collins, Eugene C. Butcher, Ahmad Kamal, and M. Bishr Omary University of Michigan Medical School, Department of Molecular and Integrative Physiology, Ann Arbor, Michigan; Stanford University School of Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Stan...

Traumatic brain injury (TBI) and stroke are the major causes of brain damage and chronic neurological impairments. There is no agreed-upon effective metabolic intervention for TBI and stroke patients with chronic neurological dysfunction. Clinical studies published this year present convincing evidence that hyperbaric oxygen therapy (HBOT) might be the coveted neurotherapeutic method for brain ...

Defects in the development of the brain have a profound impact on mature brain functions and underlying psychopathology. Classical neurotransmitters and neuromodulators, such as dopamine, serotonin, norepinephrine, acetylcholine, glutamate and GABA, have pleiotropic effects during brain development. In other words, these molecules produce multiple diverse effects to serve as regulators of disti...