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Injuries are a public health crisis. Neurotrauma, specific type of injury, is leading cause death and disability globally, with the largest burden in low- middle-income countries (LMICs). However, there lack quality neurotrauma-specific data LMICs, especially at national level. Without standard criteria for what constitutes registry, significant challenges frequently preventing this level colle...

BACKGROUND Rehabilitation interventions are a key component of the services required by individuals with neurotrauma to recover or compensate for altered abilities and achieve optimal social participation. Primary studies have produced evidence of the effect of rehabilitation length of stay on individuals with neurotrauma. However, to date no systematic review of this evidence has been performe...

s and Conference Presentations: Hartings JA, Okonkwo DO, Bullock MR, Shutter LA, Mathern B, Strong AJ. Spreading depolarizations and outcome after traumatic brain injury: a prospective observational study. Military Health System Research Symposium (8 Aug 2012; Ft. Lauderdale, FL). Hartings JA, Bullock MR, Zacko C, Vidgeon S, Ridder T, Stanger R, Fabricius M, Mathern B, Tolias C, Pahl C, Strong ...

The past decade has witnessed a resurgence of interest in the use of hypertonic saline for low-volume resuscitation after trauma. Preliminary studies suggested that benefits are limited to a subgroup of trauma patients with brain injury, but a recent study of prehospital administration of hypertonic saline to patients with traumatic brain injury failed to confirm a benefit. Animal and human stu...

The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in numerous brain pathologies including neurotrauma and ischaemic stroke. Tissue plasminogen activator is a serine protease that converts plasminogen to plasmin, a protease that dissolves blood clots. Besides its role in fibrinolysis, tissue plasmi...

The involvement of NMDA-type glutamate receptor in neuronal injury established in experimental stroke and neurotrauma models has been recently challenged by failures in treatment of stroke/neurotrauma patients with NMDA receptor antagonists. NMDA receptor activity is known to be essential for mediating a multitude of physiological functions. However, how NMDA receptors are recruited to cause ne...