Noise-induced hearing loss (NIHL) is a growing health issue, with costly treatment and lost quality of life. Here we establish Drosophila melanogaster as an inexpensive, flexible, and powerful genetic model system for NIHL. We exposed flies to acoustic trauma and quantified physiological and anatomical effects. Trauma significantly reduced sound-evoked potential (SEP) amplitudes and increased S...

Although Noise Induced Hearing Loss (NIHL) is well recognised there are an increasing number of associations that are important in its study and to a lesser extent in clinical practice. For many there is controversy over whether there is a causal relationship or a confounding effect but of these presbyacusis is the most important. The PULHHEEMS assessment H3 is currently the first level of abno...

OBJECTIVES To investigate the relation between different types of exposure to noise and a classic sign of noise induced hearing loss (NIHL), the audiometric notch. METHODS The study sample had exposure to both continuous and impulse noise and was drawn from a population of electrical transmission workers. Audiograms, taken as part of a hearing conservation programme, were read by three clinic...

BACKGROUND Recent studies have evaluated the associations between polymorphisms of the heat-shock protein 70 (HSP70) encoding genes and noise-induced hearing loss (NIHL). However, the conclusions of these studies are conflicting. The objective of this meta-analysis was to clarify the association between all known polymorphisms of HSP70 genetic loci and susceptibility to NIHL, based on existing ...

Noise-induced hearing loss (NIHL) is one of the most frequent disabilities in industrialized countries. It has been demonstrated that hair cell loss in the auditory end organ may account for the majority of ear pathological conditions. Previous studies have indicated that histone deacetylases (HDACs) play an important role in neurodegenerative diseases, including hearing impairment, in older pe...

noise-induced hearing loss (nihl) is the most common complication of long-term noise exposure, though there  are  some  other  complications  due  to  exposure  to  noise.  metabolic  complications  of  the  noise exposure are being evaluated in recent studies. we aimed to assess the relationship between nihl and lipid profile, and fasting blood sugar (fbs). in this cross-sectional  study, 462 ...

Background: A high prevalence of noise-induced hearing loss (NIHL) is observed amongst employees in the steel manufacturing industry. Objective: To determine the prevalence of NIHL and current noise abatement techniques implemented at a steel manufacturing plant. Methods: Structured questionnaires were completed by permanent employees at a steel-manufacturing plant for the purpose of collecting...

BACKGROUND Noise-induced hearing loss (NIHL) is a common but preventable disability. The purpose of this study was to assess the understanding of NIHL in a community sample in the context of exposure to portable music players, including MP3 players, and personal hearing acuity as tested with the Welch Allyn Audioscope 3. METHODS A cross-sectional convenience sample of 94 adults (18 to 65 year...

Noise-induced hearing loss (NIHL) results from the damage of the delicate hair cells inside the ear after excessive stimulation of noise. Unlike certain lower animals such as amphibians, fishes, and birds, in humans, hair cells cannot be regenerated once they are killed or damaged; thus, there are no therapeutic options to cure NIHL. Therefore, it is more important to protect hair cells from th...

DNA damage to cochlear hair cells caused by 8-oxoguanine (8-oxoG) is essential for the development of noise-induced hearing loss (NIHL). Human 8-oxoG DNA glycosylase1 (hOGG1) is a key enzyme in the base excision repair (BER) pathway that eliminates 8-oxoG. Many epidemiological and functional studies have suggested that the hOGG1 Ser326Cys polymorphism (rs1052133) is associated with many disease...