Structural investigations of peptides using NMR spectroscopy rarely include the detection of N-H···O=C and N-H···N hydrogen bonds, because the relevant heteronuclei have a low natural abundance while the small trans hydrogen bond scalar couplings reduce the sensitivity. Fast repetition NMR techniques combined with state of the art spectrometer specifications allowed the enhancement of the sensi...

Submit Manuscript | http://medcraveonline.com Abbreviations: EC50: Half Maximal Effective Concentration; MIC: Minimum Inhibitory Concentration; TLC: Thin-Layer Chromatography; PTLC: Preparative Thin Layer Chromatography; FTIR: Fourier Transform Infrared Spectroscopy; HRMS E: High-Resolution Mass Spectrometer Electron Ionization; 1H NMR; Proton Nuclear Magnetic Resonance; 13C NMR; Carbon Nuclear...

Background: Sodium valproate (VPA), an anticonvalsant drug, has been reported to stimulate viral replication.  A combination therapy with VPA and acyclovir (ACV) is used for the treatment of herpesvirus encephalitis, the commonest sporadic encephalitis of viral origin. Objective: To determine a possible interaction between VPA and ACV leading to a modification of antiviral activity of ACV. Meth...

The reaction was carried out in dry EtOH under an argon atmosphere and at room temperature. NMR spectrum was recorded with a Bruker Avance 300 spectrometer and all chemical shifts are reported relative to the solvent signal [CDCl3: 7.26 ppm ( H)]. The assignments of the NMR signals were carried out under using 2D-NMR experiments H-HCOSY. IR spectra were recorded with a Thermo Nicolet NEXUS FTIR...

With SGF Profiling™ we introduce an NMR-based screening method for the quality control of fruit juices. This method has been developed in a joint effort by Bruker BioSpin GmbH and SGF International e.V. The system is fully automated with respect to sample transfer, measurement, data analysis and reporting and is set up on an Avance 400 MHz flow-injection NMR spectrometer. For each fruit juice a...

The use of 270 MHz Fourier Transform nuclear magnetic resonance (NMR) spectrometer, combined with signal processing techniques to improve resolution, enabled proton resonances from the individual aromatic residues of haemoglobin to be distinguished. In the presence of clinical concentrations of the general anaesthetic drugs halothane and methoxyflurane, specific changes in the NMR spectrum can ...

Water has a significant impact on the properties of building materials. A nuclear magnetic resonance (NMR) spectrometer can be used to detect water in materials and measure its distribution nondestructively, rapidly, accurately. In this paper, novel method is introduced for using single-sided NMR content (WC) materials, including brick, sandstone, mortar, concrete. The signal intensity these we...

This paper describes the design and construction of a personal computer (PC) based pulsed NMR spectrometer to measure spin-lattice relaxation times in solids. The spectrometer works at 10 MHz and produces d. pulses of amplitude 200 Vp_p' The pulse programmer provides various pulse sequences such as 180°-1"-90°and 90°-1"-180°and inter pulse intervals (1")can be computer programmed. The rise and ...