OBJECTIVE To conduct a systematic review of rigorously evaluated treatments for infant colic. METHODS Online bibliographic databases were searched for the term "colic" in articles classified as clinical trials or randomized controlled trials and conducted in infants. Reference lists from review articles, meta-analyses, and the selected articles were also reviewed for potential studies. The ab...

OBJECTIVE To examine the performances of an alternative strategy to decide initiating BP-lowering drugs called Proportional Benefit (PB). It selects candidates addressing the inequity induced by the high-risk approach since it distributes the gains proportionally to the burden of disease by genders and ages. STUDY DESIGN AND SETTING Mild hypertensives from a Realistic Virtual Population by ge...

The number needed to treat (NNT) is a simple measure of a treatment's impact, increasingly reported in randomized trials and observational studies, but often incorrectly calculated in studies involving varying follow-up times. We discuss the NNT in these contexts and illustrate the concept using several published studies. While the computation of the NNT is founded on the cumulative incidence o...

The number needed to treat (NNT) and its counterpart, the number needed to harm (NNH), are commonly used measures of effect in studies of mental health treatments. The NNT is an absolute measure, which conveys a more direct and intuitive impression of the effect on an individual than the absolute risk reduction (ARR). To illustrate this, consider an imaginary trial comparing the effects of cogn...

BACKGROUND The number needed to treat (NNT) has been promoted as the preferred effect measure when patients and physicians share decision making. Our aim was to explore the impact of the NNT on laypeople's decisions about preventive drug therapies. METHODS Two thousand subjects were selected for the survey; 1201 (60%) responded for a representative sample of the Norwegian population. Responde...

The aim of this study was to evaluate the efficacy of vilazodone using different definitions of remission. Post-hoc analyses were carried out using data from an 8-week, multicenter, randomized, double-blind, placebo-controlled trial of vilazodone 40 mg/day in adults with major depressive disorder (NCT01473394). The primary efficacy endpoint was a mean change in the Montgomery-Åsberg Depression ...

This paper describes a high level library (The Nearest Neighbor Tool: NNT) that has been used to parallelize operational weather prediction models. NNT is part of the Scalable Modeling System (SMS), developed at the Forecast Systems Laboratory (FSL). Programs written in NNT rely on SMS's run-time system and port between a wide range of computing platforms, performing well in multiprocessor syst...

In major depression, when a first antidepressant does not cause remission of symptoms (60%-75%), there are several options for continuing treatment in the next step. This study is a cost-utility analysis (CUA) of different second-line approaches. In a simulated trial outpatients with MDD were treated with citalopram for 13 weeks (level 1), then based on two alternative algorithms implemented fr...

BACKGROUND Benign prostatic hyperplasia affects older men. This systematic review determined efficacy and adverse effects of finasteride. REVIEW METHODS PubMed, the Cochrane Library, reference lists of reports, and reviews were searched for randomised, double-blind trials of finasteride in benign prostatic hyperplasia. Outcomes included symptom score, urinary flow rate, prostate volume, disco...

AIMS Controversy exists about the clinical significance of in-stent late loss (ISLL) after drug-eluting stent (DES) implantation. We sought to clarify whether ISLL after DES implantation is related to a potential clinical impact. METHODS AND RESULTS We included in a meta-regression analysis 21 trials (8641 patients) that randomly compared DES with bare-metal stents (BMS). We evaluated the rel...