In the last twenty years, the treatment of coronary heart disease with cardiac catheterization has greatly advanced. This therapeutic approach has had unexpected side effects, however, for which solutions must be found, particularly in the are of interventional cardiology. The “noreflow” phenomenon, a side effect, is an uncommon and critical occurrence and, if not reversed, causes a high rate o...

Phenomenon in Acute Myocardial Infarction Dr. Iwakura and colleagues in a recent issue of the Journal (1) conclude that, from a retrospective analysis of 146 patients, hyperglycemia might be associated with impaired microvascular function after acute myocardial infarction. The investigators describe an independent relation between elevated blood glucose levels on admission and no-reflow phenome...

Recent evidence shows that circulating granulocytes play an important role in capillary stasis and tissue injury. We investigated two aspects of the problem in a Wiggers hemorrhagic shock model of the rat: the survival rate and the microvascular no-reflow phenomenon. A conventional group of rats with normal blood cells and a neutropenic group of rats pretreated with intraperitoneal antigranuloc...

In the setting of acute myocardial infarction, early and adequate reopening of an infarct-related artery is not necessarily followed by a complete restoration of myocardial perfusion. This condition is usually defined as 'no-reflow'. The pathophysiology of no-reflow is multifactorial since extravascular compression, microvascular vasoconstriction, embolization during percutaneous coronary inter...

The progress in reperfusion therapy dictated the necessity for developing new tools and procedures for adjacent/additional therapy of acute cardiovascular disorders. The adjacent therapy is targeted on the damage of the microcirculation, leading to the unfavorable prognosis for the patients. The no-reflow phenomenon holds special place in the multifactorial etiology of the microcirculation diso...

BACKGROUND No-reflow phenomenon after percutaneous coronary intervention (PCI) in patients with acute ST-segment-elevation myocardial infarction (STEMI) is relatively common and has therapeutic and prognostic implications. Cigarette smoking is known as deleterious in patients with coronary artery disease (CAD), but the effect of smoking on no-reflow phenomenon is less investigated. The aim of t...

PURPOSE To review (1) the mechanisms of coronary microvascular reperfusion injury, particularly in the relationships between microvascular endothelium dysfunction, microstructure damage, microemboli and no-reflow phenomena; (2) the no-reflow presentation and management at ischemia-reperfusion to suggest future direction for no-reflow therapy in acute myocardial infarction. SOURCES Original ar...