Thrombosis can be life threatening, necessitating therefore its instant treatment. Hydergine, a nootropic agent is used as a cognition enhancer in stroke patients but relatively little is known about its anti-thrombolytic effect. To investigate this aspect, in vivo and ex vivo experiments were designed and conducted. Three groups of rats were injected 1.5mg, 3.0mg and 4.5mg hydergine intraperit...

It is widely believed that nootropic (cognition-enhancing) agents produce their therapeutic effects by augmenting excitatory synaptic transmission in cortical circuits, primarily through positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors (AMPARs). However, GABA-mediated inhibition is also critical for cognition, and enhanced GABA function may be likewise ther...

BACKGROUND & OBJECTIVES A large number of plants have been recognized to be effective in the treatment of diabetes mellitus. Persistent hyperglycaemia is associated with decreased function of immune system and cerebral ischaemia mainly due to increased oxidative stress and inflammatory response. Andrographis paniculata is a medicinal plant widely used in folk medicine for various purposes. In t...

Introduction: Psychomotor performance task is used to assess the arousal and cognitive functions of the central nervous system. Alternatively, human visual working memory reflects the capability of the individual’s short-term memory. Psycho-mental stimuli are linked to the stimulation of Malondialdehyde (MDA) formations. Citicoline is a nootropic nucleotide agent with a favorable effect on the ...

BACKGROUND Few studies have examined the contribution of treatment on the mortality of dementia based on a population-based study. OBJECTIVE To investigate the effects of anti-dementia and nootropic treatments on the mortality of dementia using a population-based cohort study. METHODS 12,193 incident dementia patients were found from 2000 to 2010. Their data were compared with 12,193 age- a...

Objective: Circadian rhythms are present almost in all living organisms and synchronized with the zeitgebers (time givers), especially lightdark (LD) cycles. The jetlag rotating shift work schedules lead to desynchronization of circadian clock which may cause various health problems. Studies have shown that withanolide-A (WA) is a potent nootropic neuroprotective agent found Withania somnifera....

The aim of present study is to investigate neuroprotective and nootropic activity of Petroleum Ether Extract of Carica papaya seeds (PEECPS) on diabetic induced cognitive decline rats. Rectangular maze and morris water maze models were used to evaluate nootropic activity and neuroprotective effects were studied by estimating acetyl cholinesterase (AchE), malondialdehyde (MDA), superoxide dismut...

Cordiceps sinensis is age old herb in traditional Chinese herbology. It has been widely researched. It is true Rasayan (Rejuvenator / Antiaging ) herb as it is immunomodulator, adaptogen, antioxidant, anti-cancer, neuroprotective, nootropic, aphrodisiac and hepatoprotective. Additionally it protects kidney, GIT , provides stamina and relieves fatigue. This review is an abridged version as the v...

The article is devoted to the comparison of nootropic activity grape polyphenoles in resveratrol and food concentrate “Enoant” at doses 20 mg/kg, using Barnes maze animals. It was found out that demonstrate positive effect maze, which expressed by changes time spent on searching for a burrow number incorrect definitions true burrow.

Informative parameters of normalized electrograms the brain cats under action regulatory neuropeptides with nootropic properties were established using example Semax drug. The results obtained confirmed by a comparative pharmaco-EEG analysis various pharmacological agents directed action. pronounced stable activating and effects this group in are distinguished unidirectional that coincides data...