We have analyzed the extent of regulation by the nitric oxide (NO)-sensitive repressor NsrR from Neisseria meningitidis MC58, using microarray analysis. Target genes that appeared to be regulated by NsrR, based on a comparison between an nsrR mutant and a wild-type strain, were further investigated by quantitative real-time PCR, revealing a very compact set of genes, as follows: norB (encoding ...

Neisseria gonorrhoeae, the etiologic agent of gonorrhea, is frequently asymptomatic in women, often leading to chronic infections. One factor contributing to this may be biofilm formation. N. gonorrhoeae can form biofilms on glass and plastic surfaces. There is also evidence that biofilm formation may occur during natural cervical infection. To further study the mechanism of gonococcal biofilm ...

Nitric oxide reduction in Ralstonia eutropha H16 is catalysed by the quinol-dependent NO reductase NorB. norB and the adjacent norA form an operon that is controlled by the sigma(54)-dependent transcriptional activator NorR in response to NO. A NorR derivative containing MalE in place of the N-terminal domain binds to a 73 bp region upstream of norA that includes three copies of the putative up...

This paper considers the effects of turbulence on mean motion resonances in extrasolar planetary systems and predicts that systems rarely survive in a resonant configuration. A growing number of systems are reported to be in resonance, which is thought to arise from the planet migration process. If planets are brought together and moved inward through torques produced by circumstellar disks, th...

Artificial General Intelligence will not be general without computer vision. Biologically inspired adaptive vision models have started to outperform traditional pre-programmed methods: our fast deep / recurrent neural networks recently collected a string of 1st ranks in many important visual pattern recognition benchmarks: IJCNN traffic sign competition, NORB, CIFAR10, MNIST, three ICDAR handwr...

Rhodobacter sphaeroides 2.4.1, which is incapable of denitrification, has been found to carry nnrR, the nor operon, and nnrS, which are utilized for denitrification in R. sphaeroides 2.4.3. The gene encoding nitrite reductase was not found in 2.4.1. Expression of beta-galactosidase activity from a norB-lacZ fusion was activated when cells of 2.4.1 were incubated with NO-producing bacteria. This...

We describe how the pretraining algorithm for Deep Boltzmann Machines (DBMs) is related to the pretraining algorithm for Deep Belief Networks and we show that under certain conditions, the pretraining procedure improves the variational lower bound of a two-hidden-layer DBM. Based on this analysis, we develop a different method of pretraining DBMs that distributes the modelling work more evenly ...

Restricted Boltzmann machines were developed using binary stochastic hidden units. These can be generalized by replacing each binary unit by an infinite number of copies that all have the same weights but have progressively more negative biases. The learning and inference rules for these “Stepped Sigmoid Units” are unchanged. They can be approximated efficiently by noisy, rectified linear units...