نتایج جستجو برای: notch
تعداد نتایج: 18823 فیلتر نتایج به سال:
The Drosophila glucoside xylosyltransferase Shams xylosylates Notch and inhibits Notch signaling in specific contexts including wing vein development. However, the molecular mechanisms underlying context-specificity of the shams phenotype is not known. Considering the role of Delta-Notch signaling in wing vein formation, we hypothesized that Shams might affect Delta-mediated Notch signaling in ...
T -cell acute lymphoblastic leukemia (T-ALL) is an aggressive leukemia with a poor outcome. The majority of human T-ALL has gain-of-function (activating) mutations in Notch-1,1 implicating Notch-1 as a central component in the pathogenesis of T-ALL. Notch proteins are widely expressed transmembrane receptors involved in many cellular processes such as differentiation, proliferation, and apoptos...
this paper presents an e-ring shaped printed monopole antenna for uwb applications with dual notched bands performance. in order to generate single frequency band notch function, we applied a u-ring shaped monopole antenna, and by inserting a rectangular ring in the centre of it an e-ring shaped radiating patch created and a dual band-notch function can be achieved. the measured bandwidth of th...
Notch is a transmembrane receptor that mediates the cell-cell interactions necessary for many cell-fate decisions. Endocytic trafficking of Notch plays important roles in the activation and downregulation of this receptor. A Drosophila O-FucT-1 homolog, encoded by O-fut1, catalyzes the O-fucosylation of Notch, a modification essential for Notch signaling and ligand binding. It was recently prop...
Notch receptors are involved in regulating the balance between cell differentiation and stem cell proliferation during the development of numerous tissues (Artavanis-Tsakonas, S., Matsuno, K., Fortini, M. E., 1995. Notch signaling. Science 268, 225-232). Here the expression of all four vertebrate Notch genes, their ligands, and some down-stream targets is analyzed during mouse pancreatic organo...
The Notch signaling pathway is highly conserved across different animal species and plays crucial roles in development and physiology. Regulation of Notch signaling occurs at multiple levels in different tissues and cell types. Here, we show that the histone deacetylase HDAC1 acts as a positive regulator of Notch signaling during Drosophila wing development. Depletion of HDAC1 causes wing notch...
Little is known of microRNA interactions with cellular pathways. Few reports have associated microRNAs with the Notch pathway, which plays key roles in nervous system development and in brain tumors. We previously implicated the Notch pathway in gliomas, the most common and aggressive brain tumors. While investigating Notch mediators, we noted microRNA-326 was upregulated following Notch-1 knoc...
زمینه وهدف: ملانومای متاستاتیک بدخیمترین نوع سرطان پوست است؛ سختیهای درمان ملانوما به وجود سلولهای بنیادی سرطان در ملانوما نسبت داده شدهاند. خصوصیات سلولهای بنیادی سرطانی میتواند بهوسیله به هم خوردن تنظیم مسیرهای پیامرسانی سلولی Notch و Wnt به دست بیاید. هدف ما از این مطالعه به دست آوردن سلولهای بنیادی ملانوما از رده سلولی متاستاتیک A375 و سپس بررسی خودنوزایی و خصوصیا...
The Notch signaling pathway controls diverse cell-fate specification events throughout development. The versatility of this pathway to influence different aspects of development comes from its multiple levels of regulation. Upon ligand-induced Notch activation, the Notch intracellular domain (Notch-ICD) is released from the membrane and translocates to the nucleus, where it transduces Notch sig...
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