This article reviews the performance of first trimester screening for chromosomal anomalies using various combinations of ultrasound and maternal serum biochemical modalities. Detection rates in excess of 90% can be routinely achieved for Trisomy 21, Trisomy 13, Trisomy 18 using a combination of fetal nuchal translucency (NT) thickness and maternal serum free ss-hCG and PAPP-A at 11 + 0 to 13 +...

OBJECTIVE To examine the significance of fetal nuchal translucency at 10-14 weeks' gestation in the prediction of abnormal fetal karyotype. DESIGN Prospective screening study. SETTING The Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London. SUBJECTS 827 fetuses undergoing first trimester karyotyping by amniocentesis or chorionic villus sampling. MAIN OU...

2.1 Risk of delivery at ,30 (%) Risk of delivery at ,34 (%) Risk of delivery at ,37 (%) Positive fFN + CL (25 mm 7.14 38.5 46.2 Positive fFN + CL .25 mm 10.0 22.2 25.0 Negative fFN + CL (25 mm 0.0 5.5 11.8 Negative fFN + CL .25 mm 0.0 3.6 10.0 fFN, fetal fibronectin. Oral presentations Arch Dis Child Fetal Neonatal Ed 2009;94(Suppl I):Fa4–Fa10 Fa5 group.bmj.com on October 19, 2017 Published by ...

Twin-twin transfusion syndrome is a major complication of monochorionic twin pregnancies. In foetuses from monochorionic twinning the presence of increased nuchal translucency thickness (NT) has been associated with an increased risk of developing this syndrome. One of the presumed mechanisms of increased NT is early cardiac failure, indirectly indicated by abnormal blood flow in the ductus ven...

OBJECTIVES The cost-effectiveness of opportunistic nuchal translucency ultrasound screening in pregnancy was compared with alternative screening strategies for trisomy 21 in Australia. METHODS A decision analytic model was used of various pregnancy screening strategies based on a systematic review of the literature on the effectiveness of nuchal translucency ultrasound and serum screening and...