Defects in the biogenesis of lamin A from its farnesylated precursor, prelamin A, lead to the accumulation of prelamin A at the nuclear envelope, cause misshapen nuclei, and result in progeroid syndromes. A deficiency in ZMPSTE24, a protease involved in prelamin A processing, leads to prelamin A accumulation, an absence of mature lamin A, misshapen nuclei, and a lethal perinatal progeroid syndr...

background: the studies have indicated that inter marriage would increases the frequency of congenital disabilities compared with non-inter marriages. it seems that in our country inter marriage is one of the most important factors for disabilities in infants. this research was conducted to compare the relative frequency of congenital disabilities with type of marriage in jiroft city, which has...

The objective of the study was to check the occurrence of phenotypic manifestations of germinal mutations in children born within a 30 km radius of the Paks nuclear power plant, Hungary. The study took the form of a comparative analysis between observed and expected rates based on the Hungarian baseline rates, as well as between children born before and after the operation of the nuclear plant....

Background and aim: Increased rate of micronucleus in buccal mucosa cells and its correlation with carcinogenesis is worth consideration. Recently, occupation in dental laboratories has been proposed as a predisposing factor. Therefore, the present study aimed to evaluate the effect of occupational exposure on buccal mucosa cells of dental laboratory technicians. Materials and methods: This ...

BACKGROUND/AIMS Previously, we showed that activation of the beta-catenin/Wnt pathway is a dominant event during c-Myc/E2F1 hepatocarcinogenesis. Majority of c-Myc/E2F1 HCCs displayed nuclear accumulation of beta-catenin in the absence of beta-catenin mutations, suggesting that alterations in other members of the Wnt pathway might be responsible for nuclear localization of beta-catenin. Here, w...

We evaluated micronucleus and apoptosis occurrence among women with normal smears and women with different kinds of cervical abnormalities, i.e., inflammatory processes and low- and high-grade squamous intraepithelial lesions (N = 12, N = 10 and N = 27, respectively). The sample included 59 women who were seen at a public medical service for cervical cancer prevention in Feira de Santana, Bahia...

Studies of fetal hemoglobin and bone marrow ultrastructure were performed on a patient with a recently described syndrome consisting of lymphosarcoma, short stature, defective cellular Immunity, hypogammaglobulinemia, and mosaicism for a marker chromosome. Abnormalities of the erythroid cells, including multinucleated erythroblasts, nuclear bodies, megaloblasts, and frayed cytoplasm, were seen ...

abstract background and aim: increased rate of micronucleus in buccal mucosa cells and its correlation with carcinogenesis is worth consideration. recently, occupation in dental laboratories has been proposed as a predisposing factor. therefore, the present study aimed to evaluate the effect of occupational exposure on buccal mucosa cells of dental laboratory technicians. materials and methods:...

background: biomonitoring provides a useful tool to estimate the genetic risk from exposure to genotoxic agents. the aim of this study was to assess the potential cytogenetic damage associated with occupational exposure to hexavalent chromium by using micronuclei (mn) as a biomarker. methods: this was a cross-sectional study and all participants were males. both the exposed and control individu...

Glyphosate is a widely used broad-spectrum weed control agent. In the present study, an in vivo study on the genotoxic effects of a technical herbicide (Roundup) containing isopropylamine salt of glyphosate was carried out on freshwater goldfish Carassius auratus. The fish were exposed to three doses of glyphosate formulation (5, 10 and 15 ppm). Cyclophosphamide at a single dose of 5 mg/l was u...