background: epilepsy is the second common neurologic disorder. although many antiepileptic drugs have been formulated to control the seizures, but not all seizures have been controlled by them. uncontrolled epilepsy can actually reduce the patients’ quality of life. objectives: identifying the proportion of adult intractable epilepsy among epileptic patients in an area in the north east of iran...

Epilepsy is a major health problem, it being among the most common chronic neurologic pathologies. Its basic therapy via anti-seizure drugs (ASDs), of which nearly two dozen are currently available for symptomatic treatment epileptic seizures. But, notwithstanding increasing ASD options, about one-third patients remain drug-refractory, and this fraction did not diminish over decades. This paper...

Epilepsy is among the most common serious neurological disorders and affects around 50 million people worldwide, 80% of which live in developing countries. Despite introduction several new Anti-Epileptic Drugs (AEDs) last two decades, one third treated patients have seizures refractory to pharmacotherapy. This highlights need develop treatments with drugs targeting alternative seizure-induction...

Introduction: FDG Brain PET is a valuable paraclinical tool for presurgical assessments of patients suffering from refractory epilepsy. By the widespread accessibility of PET, recognizing the functional lesions has become a current practical method especially in preoperative evaluations of the partial epilepsy disorders. The aim of our study was to assess the impact of quantit...

while the introduction of radioactive tracers in the study of metabolic pathways has been well-documented in clinical thyroidology as early as 1924, the widespread utilization in other clinical specialties has been hampered by slow developments in radiation-detecting devices and in the production of appropriate radiopharmaceuticals, in addition tothe morbid fear of radiation. in the philippines...

in 1955, the first nuclear medicine division was established in thailand by professor romsai suwannik in the department of radiology, siriraj hospil, mahidol university in bangkok. in 1959 four years later, the second nuclear medicine division was established in the department of radiology, chulalongkorn hospital in bangkok. the third nuclear medicine division was started in rajvithi hospital i...

OBJECTIVES To review the current evidence base for the diagnosis and management of the childhood epilepsies and to draw attention to the current gaps in this evidence base. The focus will be on therapeutic aspects. Current International League Against Epilepsy (ILAE) terminology will be described and used throughout the discussion. The review will draw attention to recent advances that have bee...

From the Departments of Neurology and Neurobiology and the Brain Research Institute, UCLA School of Medicine, Los Angeles. Address reprint requests to Dr. Engel at the Reed Neurological Research Ctr., 710 Westwood Plaza, Los Angeles, CA 90095-1769. Supported in part by grants (NS-02808, NS-15654, NS-33310, and GM24839) from the National Institutes of Health and a contract (DE-AC03-76SF00012) wi...

PURPOSE To assess the impact of perceived stigma on the quality of life of Bulgarian patients with refractory epilepsy. METHODS We studied 70 adult patients with refractory epilepsy, without cognitive impairment, progressive somatic, neurological disease or recent seizures, and 70 patients with pharmacosensitive epilepsy. All participants completed a 3-item stigma scale, the patients with ref...

Objective: To evaluate the therapeutic effect of the use of immunoglobulin in patients with refractory epilepsy. Methods: Twenty patients with refractory epilepsy were treated with immunoglobulin therapy. Results: Five patients became free from seizures. Thirteen patients improved 50-80% and two patients had no reduction in number of seizures. Conclusions: All patients benefited significantly a...