CONTEXT The mechanisms responsible for impaired chylomicron metabolism have not been adequately investigated in obese subjects. OBJECTIVE We aimed to compare apolipoprotein (apo) B-48 kinetics in obese and lean men by developing a new model to describe the kinetics of apoB-48 particles in the postprandial state. DESIGN, SETTING, AND PATIENTS Seven obese and 13 age-matched lean men were give...

to investigate the effect of exercise on cortisol responses and energy expenditure in obese and lean men, we measured the energy expenditure (ee) and salivary cortisol responses of six obese (age 22.83± 1.9 yr; vo2max,35.45±3.9 ml/min/kg; bmi 18.2±1.3 kg/m2) sedentary men. the protocol was running on a treadmill for 30 minutes with 65% maximal oxygen consumption. student t-test and one-way anov...

The influence of obesity on the lipolytic capacity of isolated sc fat cells was studied prospectively in 13 women and 10 men, all obese, but otherwise healthy, before and 2 and 3 yr after weight reduction by bariatric surgery. Nonobese subjects (25 women and 17 men) without a family history of obesity served as the control group. Lipolytic capacity was determined after stimulation at different ...

11beta-Hydroxysteroid dehydrogenase type 1 (11HSD1) regenerates cortisol from cortisone within adipose tissue and liver. 11HSD1 inhibitors may enhance insulin sensitivity in type 2 diabetes and be most efficacious in obesity when 11HSD1 is increased in subcutaneous adipose biopsies. We examined the regeneration of cortisol in vivo in obesity, and the effects of the 11HSD1 inhibitor carbenoxolon...

BACKGROUND & AIMS Exercise in overweight patients with liver disease has improved liver enzymes, insulin levels and quality of life. Scientific evidence is incomplete regarding the role of exercise in the prevention of cirrhosis. We investigated the effect of exercise on the occurrence of cirrhosis in obese and overweight adults. METHODS Exercise was assessed using the 2012 Adult Preventive M...

Apelin-12 is one of the most potent forms of apelin, an adipocytokine that might contribute to the decrease in body weight. The aim of this project was to compare the level of serum apelin-12 in obese and nonobese middle-aged men and to assess the relationship of serum apelin-12 concentration with anthropometric parameters and lipid profile. In this cross-sectional study, 150 obese men (body ma...

Androgen levels are lower in obese men as compared with normal weight individuals. However, there are no safety data regarding the chronic use of androgen supplements in middle-aged men. The present study was undertaken to determine the cardiovascular and metabolic effects of chronic (10 weeks) testosterone treatment in male obese Zucker rats, starting at 22 weeks of age, when testosterone leve...

The relationship between obesity and cardiovascular disease risk factors was assessed in 3622 males and 5025 females aged 20-70 years. Body mass index, waist circumference, waist-to-height and waist-to-hip ratios were calculated. Obese men had a higher risk of hypertension, high total cholesterol (TC), high triglycerides (TG), high low-density lipoprotein cholesterol (LDL-C) and low high-densit...