Disadvantages of conventional drug delivery systems (DDS), such as systemic circulation, interaction with physiochemical factors, reduced bioavailability, and insufficient concentration at bone defect site, have underlined the importance developing efficacious local systems. Octacalcium phosphate (OCP) is presumed to be precursor biologically formed apatite, owing its similarity hydroxyapatite ...

A novel in vitro model based on a solution mainly composed of sodium, calcium, chloride and phosphate ions, was developed to study the calcification of biomaterials at near physiological conditions. This model, due to its ability to quickly calcify the tested materials, is called Accelerated Calcification Solution (ACS). PolyactiveTM 30170, PolyactiveTM 70/30 and its composites with nano-apatit...

Background: Repair of bone defects is challenging for reconstructive and orthopedic surgeons. In this study, we aimedto histomorphometrically assess new bone formation in tibial bone defects filled with octacalcium phosphate (OCP),bone matrix gelatin (BMG), and a combination of both.Methods: A total of 96 male Sprague Dawley rats aged 6-8 weeks weighing 120-150 g were randomly allocatedinto thr...

43Ca nuclear magnetic resonance (NMR) spectroscopy has been extensively applied to the detailed study of octacalcium phosphate (OCP), Ca8(HPO4)2(PO4)4.5H2O, and hybrid derivatives involving intercalated metabolic acids (viz., citrate, succinate, formate, adipate). Such phases are importance in development a better understanding bone structure. High-resolution magic angle spinning (MAS) experime...

Amelogenin proteins, the principal components of the developing dental enamel extracellular matrix, have been postulated to facilitate the elongated and oriented growth of the carbonated apatite crystals during enamel formation. We previously reported that amelogenin caused modulation of apatite crystals nucleated on a bioactive glass (Bioglass(R)) in vitro. Here, the effects of amelogenin on t...

In chemistry of inorganic crystals, the octacalcium phosphate (OCP) is an apatite based crystals and having a hydrated layers which used in producing needle or plate-shaped hydroxyapatite (HAP) nanocrystals. Although, prepared by dissolution precipitation reaction. These reaction led to hexagonal HAP nanocrystals formation under hydrothermal condition from OCP at 180 for 3 hours with pH solutio...

Bisphosphonates (BPs) are a class of synthetic pyrophosphate analogs that can prevent the loss of bone mass, given orally to treat postmenopuasal osteoporosis. It is not clear yet if the benefits of BPs include the possibility of affecting bone apatitic precursors transition for bone consolidation except for encouraging osteoclasts to undergo apoptosis. Furthermore, the complexity of the in viv...

The resorption of brushite-based bone cements has been shown to be highly unpredictable, with strong dependence on a number of conditions. One of the major factors is phase transformation, with change to more stable phases such as hydroxyapatite affecting the rate of resorption. Despite its importance, the analysis of phase transformation has been largely undertaken using methods that only dete...

Calcium phosphate (CaP) ceramics are used in orthopedics and dentistry due to their excellent osseointegration and biocompatibility. The electrodeposition of CaP on titanium alloy covered with self-assembled monolayers (SAMs) was studied with respect to the influence of chain length, end-group charge, and anchoring group. SAMs with end-groups similar to the functional groups on the side chains ...