PURPOSE The authors recently reported that sites of outflow resistance and regulation in the human eye are highly enriched in the endothelial isoform of nitric oxide (NO) synthase (ecNOS). In vasculature, ecNOS activation is associated with altered vascular resistance and, in the stomach, defects in NO are associated with pathologic gastric hypertension. Because human glaucoma sometimes is asso...

Purpose: To evaluate and compare the “in vitro” susceptibility of ocular bacterial isolates to aminoglycoside antibiotics (gentamicin and tobramycin) and to analyze the alteration in susceptibility after 14 years of introduction of tobramycin in Brazilian ophthalmic practice. Methods: The results of antibiotic susceptibility tests in a period of three years with 887 bacterial strains (Study “A”...

Ocular Surface Disease (OSD) is prevalent among medically treated patients with glaucoma. This is basically related to three key-points: OSD and glaucoma are both prevalent in elderly and are common comorbidities in the same patient; the role of the active ingredient of the medical antiglaucomatous therapy; the role of the preservative agent of this medical therapy. Considering the actual state...

Abstract Understanding the physical basis of corneal transparency has been a subject interest amongst physicists, basic scientists and ophthalmologists. Impairment clarity is significant cause visual morbidity worldwide. Thus, it essential to understand mechanisms behind how alterations due pathologies affect vision. We use Maxwell’s equations model light propagation in ocular tissues nodal dis...

BACKGROUND Others have reported ocular toxicity after adjuvant chemoendocrine therapy, but this study looked at ocular toxicity in similarly treated patients from large randomized clinical trials. METHODS Information was retrieved on incidence and timing of ocular toxicity from the International Breast Cancer Study Group (IBCSG) database of 4948 eligible patients randomized to receive tamoxif...

Protothecosis is an uncommon disease caused by a unicellular algae primarily found in organic matter, which affects humans, cattle, dogs, and cats, with reserved to poor prognosis. The infection typically begins the gastrointestinal tract, presenting as refractory diarrhea that persists for months before progressing systemic infection, involving other organs such eyes. objective of this study w...

Retinal ischemia could provoke blindness. At present, there is no effective treatment against retinal ischemic damage. Strong evidence supports that glutamate is implicated in retinal ischemic damage. We investigated whether a brief period of global or ocular hypothermia applied 24 h before ischemia (i.e. hypothermic preconditioning, HPC) protects the retina from ischemia/reperfusion damage, an...

PURPOSE To compare the functional changes in visual fields with optical coherence tomography (OCT) findings in patients with ocular hypertension, open angle glaucoma, and suspected glaucoma. In addition, our purpose is to evaluate the correlation of global indices with the structural glaucomatous defect, to assess their statistical importance in all the groups of our study, and to estimate thei...

purpose: controversy has recently risen about the presence of compensatory ocular countertorsion (coct) after head tilt. this study was performed to define the functional range of this phenomenon. methods: cycloplegic autorefraction was performed on 80 eyes with regular astigmatism 2d. objective autorefraction was performed in normal position, right and left head tilt positions of 5º, 10º, 15º,...