Owing to considerable differences observed in anatomy and physiology between paediatric subsets, it has been well established that children respond drugs differently compared adults. Furthermore, from a formulation perspective, there is distinct challenge develop dosage form capable of safely, accurately, reliably delivering the dose across whole population. Orally disintegrating mini-tablets (...

The article presents the modern treatment with stem cells in the reconstruction of ocular surface. The turnover of the stem cells, the location in the limbus areas, the importance of limbal stem cells presence, the clinical appearance of stem cell deficiency, investigations method for this illness and the management of stem cell deficiency (artificial lacrimal tear drops, mini scleral contact l...

This mini review contains a brief update on the pathogenicity of Staphylococcus epidermidis in ocular infections and it’s capability of biofilm formation and adhesion on the materials used in intraocular lens implants in cataract surgery patients. The review also gives an update on the genetic and molecular aspects in the understanding of biofilm formation by S. epidermidis strains on medical i...

Methods Data were pooled from two trials that evaluated the efficacy and safety of short-ragweed sublingual immunotherapy tablet (SLIT-T), MK-3641 (Ambrosia artemisiifolia; Merck/ALK-Abelló). Subjects with ragweed-pollen– induced AR/C were randomized ~16 weeks before the 2010 pollen season to once-daily MK-3641 (6 or 12 Amb a 1-U doses; one trial also included a no-effect dose of 1.5 Amb a 1-U)...

Myasthenia gravis (MG) is a disease of autoimmunity with variable and diverse clinical presentations. The target tissue is neuromuscular junction of skeletal muscles, where efficient nerve impulse transmission is hampered leading to less effective muscle contraction. Patients of MG usually present with bilateral ptosis, diplopia and fatigability, which may or may not coexist with generalised we...

PurposeTo determine the mechanism behind macular bulge height increase in eyes with dome-shaped macula (DSM).DesignRetrospective, observational case series.MethodsEyes presenting DSM followed up for a minimum of 1 year were examined using ocular biometry and spectral-domain optical coherence tomography at baseline end follow-up. Axial length (AL), height, central peripheral choroidal thickness ...

One of the major concerns in any pharmacological treatment is patients’ adherence to medication. However, different types ocular dosage forms might result response and compliance from patients. This study investigated compared public willingness on available for treatment. The also evaluated their new approach based knowledge, attitude, perception. was conducted between October December 2017 th...

BACKGROUND Sublingual immunotherapy (SLIT) is a safe/well-tolerated alternative to allergen injection immunotherapy for allergic rhinoconjunctivitis (ARC). Patient adherence is essential and patient-related outcome measures including treatment satisfaction are informative/indicative of adherence. OBJECTIVE The aim was to assess treatment satisfaction with five-grass pollen tablet SLIT under r...

OBJECTIVES Visual acuity is a common measurement in general practice, and the advent of new technology such as tablet computers offers a change in the way in which these tests are delivered. The aim of this study was to assess whether measurements of distance visual acuity using LogMAR letter charts displayed on an iPad tablet computer were in agreement with standard clinical tests of visual ac...

PURPOSE To test the hypothesis that mucoadhesive microdiscs formulated in a rapidly dissolving tablet can increase preocular residence time. METHODS Microparticles smaller than 10 mum in diameter were fabricated by emulsification with poly(lactic-co-glycolic acid) as a core material and, in some cases, poly(ethylene glycol) as a mucoadhesion promoter. To examine the effect of particle geometr...