Adhesion and invasion have been identified as the two key components of metastasis. The 37 kDa/67 kDa laminin receptor (LRP/LR) is thought to enhance these two processes thus endorsing the progression of cancer. Here we report on LRP/LR and the metastatic potential of MDA-MB 231 breast and WHCO1 oesophageal cancer cells. Western blot analysis revealed a significant increase in total laminin rec...

OBJECTIVE To examine the hypothesis that risk of oesophageal, but not of gastric or colorectal, cancer is increased in users of oral bisphosphonates. DESIGN Nested case-control analysis within a primary care cohort of about 6 million people in the UK, with prospectively recorded information on prescribing of bisphosphonates. SETTING UK General Practice Research Database cohort. PARTICIPAN...

BACKGROUND The aetiology of Africa's easterly-lying corridor of squamous cell oesophageal cancer is poorly understood. Micronutrient deficiencies have been implicated in this cancer in other areas of the world, but their role in Africa is unclear. Without prospective cohorts, timely insights can instead be gained through ecological studies. METHODS Across Africa we assessed associations betwe...

Adenocarcinoma of the oesophagus and gastro-oesophageal junction are rapidly increasing in incidence and have a well described sequence of carcinogenesis: the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. During recent years there have been changes in the knowledge surrounding disease progression, cancer management and histopathology specimen reporting. Tumours around the gastro-oesop...

STUDY OBJECTIVE To analyse quantitatively the relationship between gastrectomy and oesophageal cancer risk. DESIGN This was a case-control study, based on a structured questionnaire that included a problem-oriented medical history. SETTING A network of hospitals in the Greater Milan area between 1984 and 1992. SUBJECTS Subjects were 316 incident, histologically confirmed cases of oesophag...

BACKGROUND Previous studies showed that sex hormone might play a role in the development of oesophageal cancer in Western countries. However, evidence from Chinese populations is still lacking. METHODS We performed a hospital-based case-control study in Guangzhou, China. From June 2006 to May 2009, face-to-face interviews were conducted on 73 cases and 157 controls. Cases were Chinese females...

Local interactions between cancer cells and stroma can produce systemic effects on distant organs to govern cancer progression. Here we show that IGF2 secreted by inhibitor of differentiation (Id1)-overexpressing oesophageal cancer cells instigates VEGFR1-positive bone marrow cells in the tumour macroenvironment to form pre-metastatic niches at distant sites by increasing VEGF secretion from ca...

Oesophageal adenocarcinoma represents the 6th common cause of cancer related deaths. Frequently oesophageal adenocarcinomas are developed from Barret’s oesophagus, which metaplastic lesion lower third when squamous epithelium is replaced by glandular epithelium. It has been shown, that metaplasia bears risk progression into dysplasia and later malignant disease. However, this different in patie...

3 lIson DH. New developments in the treatment of oesophageal cancer. Curr Oncol Rep 2002;4:213-21. 4 Entwistle JW 3rd, Goldberg M. Multimodality therapy for resectable cancer of the thoracic esophagus. Ann Thorae Surg 2002;73:1009-15. 5 Kelsen DP, Ginsberg R, Pajakj TF, Sheahan DG, Gunderson L, Mortimer J, et al. Chemotherapy followed by surgery compared with surgery alone for localized oesopha...

Over a period of two decades the incidence of SCC has remained relatively stable or declined (particularly associated with smoking and alcohol), whilst there has been a rapid rise in the amount of AC seen, particularly in Caucasian males. [2, 3]This has now overtaken SCC as the most common form of oesophageal tumour in some developed countries. One study, however, suggests that the incidence of...