We examine the relative ability of inflation targeting and price level monetary policy rules to minimize variability business cycle fluctuations in a commodity-exporting country for supply demand shocks global commodity markets. The macroeconomic consequences oil non-oil primary commodities differ affect merits alternative frameworks. Particularly, consumption refined products demand-driven mov...

to evaluate off-label and off-nccn guidelines uses of antineoplastic drugs in a major chinese hospital.totally 1122 patients were selected from july to december 2011. then, the off-label and off-nccn guidelines uses of antineoplastic drugs were analyzed.in 798 of 1122 patients (71.12%), drugs were used for off-label. in 317 of 1122 patients (28.25%), the drugs were prescribed for off-label and ...

This paper investigates the impact of targeting key players by law enforcement on structure, communication strategies, and activities a drug trafficking network. Data are extracted from judicial court documents. The unique nature investigation – which saw player being arrested mid-investigation but police monitoring continuing for another year allows to compare network before after targeting. c...

We study two types of targeting in this paper, exogenous targeting and endogenous targeting. By exogenous targeting we mean targeting by product preferences: advertising levels and prices geared to specific consumer preferences. Exogenous targeting presumes observability of consumer preferences (or of factors correlated with them). This is the sort of targeting that is much in the news in conte...

Targeting the ubiquitin-proteasome system (UPS) and ubiquitin-like signalling systems (UBL) has been considered a promising therapeutic strategy to treat cancer, neurodegenerative and immunological disorders. There have been multiple efforts recently to identify novel compounds that efficiently modulate the activities of different disease-specific components of the UPS-UBL. However, it is evide...

Induction of type I IFNs is a fundamental cellular response to both viral and bacterial infection. The role of the transcription factor IRF3 is well established in driving this process. However, equally as important are cellular mechanisms for turning off type I IFN production to limit this response. In this respect, IRF3 has previously been shown to be targeted for ubiquitin-mediated degradati...

Designer nucleases have been successfully employed to modify the genomes of various model organisms and human cell types. While the specificity of zinc-finger nucleases (ZFNs) and RNA-guided endonucleases has been assessed to some extent, little data are available for transcription activator-like effector-based nucleases (TALENs). Here, we have engineered TALEN pairs targeting three human loci ...

Functional RNAi based screening is affected by large numbers of false positive and negative hits due to prevalent sequence based off-target effects. We performed a druggable genome targeting siRNA screen intended to identify novel regulators of E-cadherin (CDH1) expression, a known key player in epithelial mesenchymal transition (EMT). Analysis of primary screening results indicated a large num...

While idiotype vaccines have shown promise for B-cell malignancies, production is cumbersome; thus, targeting a common antigen on malignant B cells using an off-the-shelf approach would provide significant logistical advantages.