Mannosylerythritol lipid-A (MEL-A) is a glycolipid biosurfactant abundantly produced from soybean oil by microorganisms at a yield of up to 100 g/L. In this study, the formation of water-in-oil (W/O) microemulsion based on the single component of MEL-A was confirmed using dynamic light scattering (DLS) and freeze fracture electron microscopy (FF-EM). DLS and FF-EM measurements revealed that the...

2014 We first deduce the rigidity coefficient K of a surfactant monolayer at the oil water interface from ellipsometric measurements. For our surfactant monolayer containing alcohol, we find unusually small values of K (K ~ kB T). We then study the oil microemulsion and water microemulsion interfaces, covered with the same film. On the microemulsion side of the film we find a perturbed zone, th...

The purposes of the present study were to develop a self-microemulsifying drug delivery system (SMEDDS) containing bortezomib, a proteasome inhibitor. The solubility of the drug was evaluated in 15 pharmaceutical excipients. Combinations of oils, surfactants and cosurfactants were screened by drawing pseudo-ternary phase diagrams. The system exhibiting the largest region of microemulsion was co...

The purpose of present study was to formulate microemulsion composed of oleic acid+phosphate buffer (PB)+Tween 80+ethanol and to investigate its potential as drug delivery system for an antitubercular drug rifampicin. The pseudo-ternary phase diagram has been delineated at constant surfactant/cosurfactant ratio (K(m) 0.55). Conductivity (sigma) and viscosity (keta) studies with variation in Phi...

To improve the efficiency of the intradermal delivery of genistein and other two isoflavones (daidzein and biochanin A), we tried to clarify the usefulness of microemulsion by in vitro study on excised guinea pig dorsal skin and Yucatan micropig skin. Using microemulsion consisting of isopropyl myristate (IPM), 150 mM NaCl solution, Tween 80 and ethanol as a vehicle, the solubility of all the i...

A self-consistent picture of the structure and structural changes in a water-in-oil microemulsion (as a model of supermolecular fluids) close to the percolation threshold has been established. The self-consistency is evidenced by the demonstration that light-scattering and viscosity data for these systems can be quantitatively predicted by a model based on fractal cluster distribution. The mode...

Micro-emulsions are of great importance in food industry since they are used in various food applications. In the present study edible olive oil w/o microemulsions without the addition of a co-surfactant were studied. Both chemical and natural surfactants were examined. The chemical surfactants used were Tween 20, 40, 80 and Span 20, 80. The natural substances used as surfactants were endogenou...

Objective(s): Sesame oil is a lipophilic compound and has low aqueous solubility and low oral bioavailability. It is possible to enhance sesame oil solubility in aqueous media by applying the microemulsion system in the form of oil-in-water. In this study, the anti-cholesterol and anti-Apoptotic effects of a new combination of sesame oil and honey in a microemulsion form for cardiac muscle cell...

A robust water-in-oil microemulsion method of making water-dispersible ultra-small (<30 nm) size fluorescent chitosan nanoparticles is reported for the first time and specific targeting of these FCNPs to human leukemia cells via aptamer recognition is demonstrated.