An oncogene protein (PDB I.D-5P21) has the possible for cause of cancer. In tumour cells, they were often mutated or expressed at very high levels. Mostly normal cells experience a programmed form of death (apoptosis). It is an important and striking target for anticancer drug development and discovery. In this course we have selected about 20 anticancer drugs that target the oncogene protein. ...

Abstract This invited Team Profile was created by Kevin Li and Liliya Yatsunyk, Swarthmore College PA (USA) John Schneekloth, Jr, (Jay) National Cancer Institute, Frederick MD . They recently published an article on the first crystal structure of intercalated motif (i‐motif or iM) from HRAS oncogene involved in many cancers. The iHRAS solved to 1.8 Å resolution. It contains a tail‐to‐tail dimer...

Cancer is a complex collection of distinct genetic diseases united by common hallmarks. Here, we expand upon the classic hallmarks to include the stress phenotypes of tumorigenesis. We describe a conceptual framework of how oncogene and non-oncogene addictions contribute to these hallmarks and how they can be exploited through stress sensitization and stress overload to selectively kill cancer ...