An efficient one-pot three-component protocol for the synthesis of novel tetrahydrobenzofuran-chromone conjugates using 3-formylchromones and 1,3-cyclohexandiones in presence a variety alkyl or aryl isocyanides was developed. The reaction sequence consists an initial Knoevenagel condensation aromatic aldehydes with 1,3-cyclohexandione derivatives, followed by [4 + 1] cycloaddition isocyanides, ...