PURPOSE To quantify and compare structure and function across the macula and peripapillary area in Stargardt disease (STGD1). METHODS Twenty-seven patients (27 eyes) and 12 age-similar controls (12 eyes) were studied. Patients were classified on the basis of full-field electroretinogram (ERG) results: Fundus autofluorescence (FAF) and spectral domain-optical coherence tomography (SD-OCT) hori...

PURPOSE Glaucoma is presumed to result in the selective loss of retinal ganglion cells. In many neural systems, this loss would initiate a cascade of transneuronal degeneration. The quantification of changes in neuronal populations in the middle layers of the retina can be difficult with conventional histologic techniques. A method was developed based on multiphoton imaging of 4',6'-diamino-2-p...

We recently found that the Rb protein is important for the regulation of retinal progenitor cell proliferation and rod photoreceptor development in the mouse retina. These two functions are separate for Rb and in this study we further characterize the role of Rb in retinal development. At postnatal day 12 in the retinae of Chx10-Cre;RbLox/- mice, immature cells are found in the outer nuclear la...

Intraocular injections of low doses (0.7-1.4 mM estimated intraocular concentration) of 6-hydroxydopamine (6OHDA) selectively destroy dopaminergic neurons in the inner nuclear layer (INL) of goldfish retina, and they never regenerate. However, injection of a higher dose of 6OHDA (2.9 mM) destroys > 30% (but not all) of the cells in both the INL and the outer nuclear layer (ONL), but within 3 we...

Interphotoreceptor retinoid-binding protein (IRBP) is a classic inducer of experimental autoimmune uveoretinitis (EAU). Although IRBP causes neuronal loss in susceptible animals, resistant animals such as Sprague-Dawley (SPD) rats can benefit from the evoked protective autoimmune responses. The aim of the present study was to analyze the neuroprotective effects of IRBP against light-induced pho...

In the last few years, an increasing interest in neuroprotective effect of cannabinoids has taken place. The aim present work was to study effects modulating cannabinoid receptor 1 (CB1) context light induced retinal degeneration (LIRD), using animal model that resembles many characteristics human age-related macular (AMD) and other degenerative diseases outer retina. Sprague Dawley rats ( n = ...

Last year, the Organization of Nurse Leaders (ONL), which represents nurse leaders in Massachusetts, Rhode Island, New Hampshire, Connecticut, and Vermont, worked with England Regional Black Nurses Association (NERBNA) to create Nurse’s Pledge Champion Diversity, Equity, Inclusivity. This article details development pledge.

PURPOSE To study the changes in the outer retinal microstructures during a six month period after the onset of acute zonal occult outer retinopathy (AZOOR)-complex by spectral-domain optical coherence tomography (SD-OCT). METHODS Seventeen eyes of 17 patients with the AZOOR-complex were studied. The integrity of the external limiting membrane (ELM), ellipsoid zone (EZ; also called the inner/o...