According to the original description by Rizzolatti and colleagues, the prerequisite of triggering the discharge of mirror neurons (MNs) is the interaction of the hand with an object. On the other hand, several studies reported that the MN system in humans can be activated also by non object-directed (intransitive) movements. This difference between human and monkey MN systems has been consider...

Despite overwhelming evidence that major depressive disorder (MDD) is heritable, intensive efforts to elucidate genetic variation underlying MDD have yielded only modest success, perhaps partly because genetic effects do not directly translate into dichotomous clinical phenotypes. Biomarkers, for instance measures of brain structure and function, may represent an intermediate step in the causal...

As previously announced, ScholarOne will be used as of January 7, 2013, as our online submission system. Our whole team is enthusiastic with the new system. We advise all the authors to carefully read the instructions for authors before starting the submissions. It is a good time to thank all reviewers and authors. We also have to thank the National Council for Scientific and Technological Deve...

Abstract: The primary source of the BOLD fMRI contrast is the change in the oxygenation of blood due to mismatched changes in cerebral blood flow (CBF) and oxygen metabolism following neuronal activation. The CBF is regulated by dilation (and/or constriction) of cerebral vasculature in response to vasoactive mediators released from activated neurons and astrocytes. While a number of recent stud...

Objectives: Following focal brain trauma, multiple and evolving cellular and tissue changes affect the microstructure of the perilesional brain tissue. Some of these changes indicate damage while others are associated with a protective or regenerative response. The purpose of this work was to use high resolution diffusion MRI of ex-vivo mouse brains taken at variable times following controlled ...

Purpose: Osteoarthritis (OA) is a multifactorial disease characterized by progressive degradation of articular cartilage leading to loss of joint function. It affects several million people in the world. Currently there is no cure for OA. In a subset of patients OA is associated with hypertrophic differentiation of articular chondrocytes. This process normally occurs in the growth plate. Health...

The MMWR Weekly is now using MMWR ScholarOne Manuscripts, an online system for manuscript submissions. Launching this system provides comprehensive workflow management and streamlines the Weekly submission process.