the present investigation was focused to formulate semi-solid capsules (sscs) of hydrophobic drug telmisartan (tlms) by encapsulating semi-solid matrix of its solid dispersion (sd) in hpmc capsules. the combinational approach was used to reduce the lag time in drug release and improvise its dissolution. sds of tlms was prepared using hot fusion method by varying the combinations of pluronic-f68...

background: myocardial dysfunction is one of the major complications in patients with sepsis where there is a relationship between the blood level of cytokines and the onset of myocardial depression. in many cases of sepsis, the presence of lipopolysaccharide (lps) has been established. lps binding protein (lbp) bound endotoxin is recognized by cd14/toll-like receptor-4 (tlr4) complexes in inna...

this study examines the controlled release behavior of both water-soluble (acetaminophen, caffeine, theophylline and salicylic acid) and water insoluble (indomethacin) drugs derived from caesalpinia pulcherrima seed gum isolated from caesalpinia pulcherrima kernel powder. it further investigates the effect of incorporating diluents such as microcrystalline cellulose and lactose on caffeine rele...

Several different fuel failure criteria have been used in previously NRC-sponsored SFP accident studies. Benjamin, et. al. used the onset of runaway fuel clad oxidation as the fuel failure criterion in NUREG/CR-0649 [Ref. 1]. This criterion was criticized because clad rupture can occur at a relatively low temperature causing a gap release. The consequences of gap release can be significant if t...

The internal microstructure of a tablet, such as pore geometry and volume, impacts the tablet’s disintegration kinetics. Ideally, one could design to control dissolution onset therapeutical performance immediate-release formulas; however, manufacturing tablets with desired can be challenging due interplay between formulation process parameters. Direct quantification tablet provide framework for...

The pharmacokinetics (PK) of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not been reported, although it is very important to clinical use. In this paper, we investigated the PK of diltiazem hydrochloride delay-onset sus...