BACKGROUND Frontotemporal lobar degeneration (FTLD) consists of a clinically and neuropathologically heterogeneous group of syndromes affecting the frontal and temporal lobes of the brain. Mutations in microtubule-associated protein tau (MAPT), progranulin (PGRN) and charged multi-vesicular body protein 2B (CHMP2B) are associated with familial forms of the disease. The prevalence of these mutat...

Abstract Background The overarching goal of the Longitudinal Early‐onset Alzheimer Disease study (LEADS) is to optimally characterize early‐onset AD (EOAD) and establish an EOAD clinical trials network. Here we report baseline demographic imaging biomarker comparisons LEADS cohort late‐onset (LOAD) subjects from Alzheimer’s Neuroimaging Initiative (ADNI3). Method 123 amyloid‐positive EOAD, 47 a...

BACKGROUND Three main genes are described as causative genes for early-onset Alzheimer dementia (EOAD): APP, PSEN1 and PSEN2. We describe a woman with EOAD had a novel PSEN1 mutation. CASE REPORT A 54-year-old right-handed woman presented 12-year history of progressive memory decline. She was clinically diagnosed as familial Alzheimer's disease due to a PSEN1 mutation. One of two daughters al...

Introduction: Alzheimer’s disease (AD) is the most common cause of dementia. Early-onset AD (EOAD) occurs when it affects someone under age 65, and many people diagnosed are in their 40s 50s. Many studies literature examine caregiver burden with late-onset AH (LOAD), unclear whether experience caregiving differs according to onset AH. Aim: This study aimed determine there a difference primary i...

Being the most common cause of dementia, AD is a polygenic and neurodegenerative disease. Complex and multiple factors have been shown to be involved in its pathogenesis, of which the genetics play an indispensable role. It is widely accepted that discovery of potential genes related to the pathogenesis of AD would be of great help for the understanding of neurodegeneration and thus further pro...

BACKGROUND The underlying white matter impairment in patients with early and late-onset Alzheimer's disease (EOAD LOAD) is still unclear, this might due to the complex AD pathology. METHODS We included 31 EOAD, 45 LOAD, 64 younger, 46 elder controls our study undergo MRI examinations. Fiber density (FD) fiber bundle cross-section (FC) were measured using fixel-based analysis based on diffusion ...

introduction: artemisia dracunculus l. belongs to asteraceae family, and is a medicinal plant widely used in traditional medicine as a remedy for gastrointestinal disturbances. this study was undertaken to evaluate the effects of essential oil of a. dracunculus (eoad) on the rat alimentary tract. methods: the eoad was extracted by clevenger apparatus using hydrodistillation. ld50 was calculated...

BACKGROUND Clinically apparent Alzheimer's disease (AD) is thought to result when brain tissue damage exceeds a critical threshold of "brain reserve", a process possibly accelerated by the apolipoprotein E (ApoE) E4 allele. The interaction between onset age and ApoE genotype was investigated to assess whether early disease onset (<65 years) in patients carrying the E4 allele is associated with ...

BACKGROUND A gradual increase in the longevity due to advancement of treatment modalities and a subsequent surge in elderly population in India have led to a growing curiosity in the geriatric age group with Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) represent epiphenomena of AD. However, no comprehensive study has been carried out in South East Asia (Kas...