PURPOSE To study in situ the intraocular position of the Artisan iris-claw intraocular lens (IOL) (model 203) (Ophtec) in phakic hyperopic eyes using ultrasound biomicroscopy (UBM). METHODS Echograms of the anterior chamber were taken preoperatively and 24 to 317 days postoperatively in 4 eyes implanted with the Artisan IOL (power +4.0 to +6.0 diopters). The preoperative anterior chamber dept...

Haploinsufficiency of the transcription factor Pax6/PAX6 has been implicated in a number of congenital eye disorders in humans and mice, such as aniridia and Small-eye, which affect the development and function of the lens, cornea, anterior eye segment and neuroretina. However, the widespread distribution of Pax6/PAX6 protein within the developing and adult eye preclude the identification and d...

Small eye (Sey) mice homozygous for mutations in the Pax-6 gene have no lenses and no nasal cavities. We have examined the ontogeny of eye and nasal defects in Sey/Sey embryos and have related the defects seen to the pattern of Pax-6 mRNA expression in the mouse during normal eye and nasal development. There are two principal components of the early eye, the neural ectoderm of the optic vesicle...

The lens was the first tissue in which the concept of embryonic induction was demonstrated. For many years lens induction was thought to occur at the time the optic vesicle and lens placode came in contact. Since then, studies have revealed that lens placodal progenitor cells are specified already at gastrula stages, much earlier than previously believed, and independent of optic vesicle intera...

AIMS To investigate the adhesion characteristics of several intraocular lenses (IOLs) to the simulated and rabbit lens capsule. METHODS Adhesive force to bovine collagen sheets was measured in water with polymethylmethacrylate (PMMA), three piece silicone, and acrylic foldable IOLs. In rabbit eyes, phacoemulsification and IOL implantation were performed. Three weeks later, adhesion between th...

Evaluation of the optic nerve head includes both observational and functional studies. Direct study of the optic disc often employs the hand held ophthalmoscope with the accessory use of a green light to allow improved visualization of the nerve fiber layer. Comprehensive analysis of the optic disc is better achieved using a stereoscopic view, which can be obtained directly through the use of v...

Optic nerve-head examination is probably the most important step in the diagnosis of glaucoma and is also extremely important in monitoring patients with established glaucoma. There are several ways to clinically examine the optic nerve head, including direct ophthalmoscopy, indirect ophthalmoscopy, and slit lamp biomicroscopy with contact lenses (such as a Goldman lens), handheld lenses (such ...

BACKGROUND Paralemmin (Palm) is a prenyl-palmitoyl anchored membrane protein that can drive membrane and process formation in neurons. Earlier studies have shown brain preferred Palm expression, although this protein is a major water insoluble protein in chicken lens fiber cells and the Palm gene may be regulated by Pax6. METHODS The expression profile of Palm protein in the embryonic, newbor...

Presbyopia occurs in the aging eye due to changes in the ciliary muscle, zonular fibers, crystalline lens, and an increased lens sclerosis. As a consequence, the capacity of accommodation decreases, which hampers to focus near objects. With the aim of restoring near vision, different devices that produce multiple focuses have been developed and introduced. However, these devices are still unabl...

OBJECTIVE To analyze the surface quality of new generation phakic intraocular lenses (IOLs). DESIGN Experimental materials study. MATERIALS Three different new generation phakic IOLs: angle-fixated anterior chamber lens Chiron Vision NuVita MA20 (polymethylmethacrylate [PMMAD, iris-fixated anterior chamber lens Ophtec Artisan Iris-Claw (PMMA), posterior chamber lens Staar ICM (polymer from ...