background: laron syndrome, is a disease that treated by igf-1. this protein is a single chain and has three disulfide bonds. people with laron syndrome have low rates of cancer and diabetes, although they appear to be at increased risk of casual death due to their stature. igf-1 is synthesized by many tissues and is secreted from liver as an endocrine hormone which is transmitted to other tiss...

An optimal cost-reducing capacity-dimensioning is crucial for network operators when designing communication networks. Failure-free working as well as backup routes have to be installed in order to guarantee Quality of Service and availability requirements. With traditional network planning techniques using linear programming with the flow-approach [1] or the path-approach [2] optimal configura...

open-pit production scheduling (opps) problem focuses on determining a block sequencing and scheduling to maximize net present value (npv) of the venture under constraints. the scheduling model is critically sensitive to the economic value volatility of block, block weight, and operational capacity. in order to deal with the opps uncertainties, various approaches can be recommended. robust opti...

A bi-criteria optimization is considered whose objectives are the maximization of the load sustained by a structure and the minimization of the structure's volume. As the objectives are conflicting, the solution to the problem is of the Pareto type. The problem is elaborated for a thin-walled column of cruciform cross-section, prone to flexural and torsional buckling. A numerical example is als...

The distillation unit is one of the main units in refning companies, and it serves as the mother unit in any refnery with any degree of complexity. The optimization of this unit can increase productivity. In this study, the vacuum distillation unit of a refnery was selected as the case study. The shares of different expenses of this unit were clarifed using a novel material flow cost accoun...

The optimization problem for a column, loaded by compression forces is studied in this article. direction of the applied coincides until buckling moment with axis column. critical values are equal among all competitive designs columns. dimensional analysis eases mathematical technique problem. introduces two dimensionless factors, one total material volume and stiffness With method analysis, so...

Library preparation for next-generation DNA sequencing (NGS) remains a key bottleneck in the sequencing process which can be relieved through improved automation and miniaturization. We describe a microfluidic device for automating laboratory protocols that require one or more column chromatography steps and demonstrate its utility for preparing Next Generation sequencing libraries for the Illu...

this article deals with the issues associated with developing a new design methodology for the nonlinear model-predictive control (mpc) of a chemical plant. a combination of multiple neural networks is selected and used to model a nonlinear multi-input multi-output (mimo) process with time delays.  an optimization procedure for a neural mpc algorithm based on this model is then developed. the p...

In this study, optimization is carried out to find the optimized design of a foam-filled column for the best Specific Energy Absorption (SEA) and Crush Force Efficiency (CFE). In order to maximize SEA, the optimization gives the value of 2.3 for column thickness and 151.7 for foam length. On the other hand to maximize CFE, the optimization gives the value of 1.1 for column thickness and 200 for...