About 30% of all colorectal cancers are thought to have a genetic basis and the known predisposing genes can only account for a small fraction of cases. A previous report suggested that a colorectal cancer candidate gene, explaining at least 20% of colorectal cancer cases with family history, was located within a 25 cM region on chromosome 9q22.2-q31.3. We typed 16 polymorphic markers encompass...

Nucleoplasmins are a nuclear chaperone family defined by the presence of a highly conserved N-terminal core domain. X-ray crystallographic studies of isolated nucleoplasmin core domains revealed a β-propeller structure consisting of a set of five monomers that together form a stable pentamer. Recent studies on isolated N-terminal domains from Drosophila 39-kDa FK506-binding protein (FKBP39) and...

In this paper, we have developed an efficient method for real time computation of Center of Pressure (CoP) sway area using a fast search and sort based on a numerical approximation of the Green-Gauss method. In addition, we investigated the correlations among the velocity, acceleration, path length, sway area, and mean frequency of CoP signals during quiet standing in healthy children and in ch...

Undulatory locomotion, a gait in which thrust is produced in the opposite direction of a traveling wave of body bending, is a common mode of propulsion used by animals in fluids, on land, and even within sand. As such, it has been an excellent system for discovery of neuromechanical principles of movement. In nearly all animals studied, the wave of muscle activation progresses faster than the w...

Non-performing loans (NPLs) are essentially a product of the irrational allocation of resources. Different from other Asian countries, China's NPL issue resulted primarily from a transitioning economy dominated by the triangular relations of state-owned enterprises (SOEs), state-owned commercial banks (SOBs) and the fiscal system. Even though the total amount of NPLs in 1999 was estimated to be...

Linkage results suggest that the region of chromosome 7 containing the leptin gene cosegregates with extreme obesity; however, leptin coding region mutations are rare. To investigate whether the leptin flanking sequence and/or a larger 40-cM region (7q22.1-7q35) contributes to obesity, we genotyped individuals from 200 European American families segregating extreme obesity and normal weight (1,...

Heterogeneity in complex diseases such as Substance Use Disorder (SUD) reduces the power to detect linkage and makes replication of findings in other populations unlikely. It is therefore critical to refine the phenotype and use methods that account for genetic heterogeneity between families. SUD was operationalized as diagnosis of abuse or dependence to alcohol and/or any one of five illicit s...

NPL operates a system of two primary caesium fountain clocks consisting of a fully characterised standard NPL-CsF2 together with a new standard NPL-CsF3, which has recently become operational. Both fountains feature a single-stage vapour-loaded magneto-optical trap as the source of cold atoms and an approximate cancellation of the potentially large cold collision frequency shift. As a result, t...

Classification of whether recovery of non-performing loans NPL is zero or positive is not only important in management of non-performing loans, but also is essential for estimating recovery rate and implementing the new Basel Capital Accord. Based on the largest database of NPL’s recovering information in China, this paper tries to establish discriminant models to predict the loan with zero rec...

This study aims to analyze the effect of Loan Deposit Ratio (LDR) and Earning Asset Quality (EAQ) on Non-Performing (NPL) before during Covid-19 pandemic. The data used in this are quarterly reports rural banks Central Java from 174 banks. Data analysis was carried out by comparing multiple linear regressions results show that pandemic can strengthen negative relationship between LDR NPL, as we...