OBJECTIVES To estimate the effect of SLE disease activity, observed over a 12-month period, on the risk of irreversible organ damage and mortality, adjusted for potential confounding factors. METHODS Patients were enrolled into a prospective cohort study and followed up from 1991. This study retrospectively analyses the data captured in the prospective cohort study. The study population consi...

OBJECTIVE To describe cumulative organ damage in juvenile dermatomyositis (JDM) patients and to identify patient characteristics and early disease variables that predict organ damage. METHODS An inception cohort of 60 patients diagnosed with JDM from 1970 to 2006 was examined, median 16.8 (2.0-38.1) years after disease onset. Disease activity was measured by the disease activity score (DAS), ...

Address for Correspondence: Akihiro Tojo, Division of Nephrology and Endocrinology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655 Tokyo-Japan Phone: 81-3-3815-5411 Ext. 37219 Fax: 81-3-3814-0021 E-mail: [email protected] Accepted Date: 15.11.2013 Available Online Date: 09.12.2013 ©Copyright 2014 by AVES Available online at www.anakarder.com doi:10.5152/akd.2013.12677 Editorial ...

A representative sample of black hypertensives has been appraised to determine candidacy for hypertension treatment. A total of 1759 black residents were successfully screened at home. Forty-one percent of the males and 33% of the females had diastolic blood pressures of 95 mm Hg or greater. They were invited for secondary screening along with those hypertensives controlled on therapy. Clinical...

Epidemiological data suggests that hypertension remains a major modifiable risk factor for cardiovascular disease in Western countries. The prevalence of the disease among adults in Slovenia aged 25–64 years is between 40–50% (CINDI, 2006). The early detection and severity of typical target organ damage and secondary diseases are key determinants of cardiovascular prognosis in patients sufferin...

BACKGROUND The assessment of target organ damage is important in the evaluation of a hypertensive patient as it provides information on the severity of the hypertension and the cardiovascular risk assessment. The aim of our study was to determine the usefulness of the chest radiograph in the assessment of target organ damage in hypertensive patients. METHODS Unselected patients attending an a...

Relations of fibrinogen to preclinical target organ damage, such as left ventricular hypertrophy, systolic dysfunction, and increased arterial stiffness while accounting for traditional risk factors, are unknown in a population-based sample free of clinically overt coronary heart disease. Therefore, we studied clinical and echocardiographic characteristics of 2709 American Indians participating...

For >50 years, it has been recognized that immunity contributes to hypertension. Recent data have defined an important role of T cells and various T cell-derived cytokines in several models of experimental hypertension. These studies have shown that stimuli like angiotensin II, deoxycorticosterone acetate-salt, and excessive catecholamines lead to formation of effector like T cells that infiltr...

Several papers have suggested that 24-hour average blood pressure (BP) is superior to office BP in relation to hypertension target organ damage. This review article will specifically address the evidence provided in this regard by either cross-sectional or longitudinal studies. It will also critically discuss the available data supporting the concept that not only 24-hour average BP values, but...